Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3691367..3692041 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ90_RS17445 Protein ID WP_003417282.1
Coordinates 3691367..3691795 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ90_RS17450 Protein ID WP_003417286.1
Coordinates 3691799..3692041 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS17420 (LVJ90_17420) 3687189..3687590 - 402 WP_003417264.1 cytidine deaminase -
LVJ90_RS17425 (LVJ90_17425) 3687827..3688165 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ90_RS17430 (LVJ90_17430) 3688162..3688596 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ90_RS17435 (LVJ90_17435) 3688725..3690497 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ90_RS17440 (LVJ90_17440) 3690497..3691288 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ90_RS17445 (LVJ90_17445) 3691367..3691795 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ90_RS17450 (LVJ90_17450) 3691799..3692041 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ90_RS17455 (LVJ90_17455) 3692163..3692777 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ90_RS17460 (LVJ90_17460) 3692774..3693439 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ90_RS17465 (LVJ90_17465) 3693440..3693973 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ90_RS17470 (LVJ90_17470) 3693970..3694344 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ90_RS17475 (LVJ90_17475) 3694441..3695577 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228558 WP_003417282.1 NZ_CP089611:c3691795-3691367 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228558 NZ_CP124322:2267104-2267206 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228558 WP_003417286.1 NZ_CP089611:c3692041-3691799 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228558 NZ_CP124322:c2267244-2266976 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References