Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3163312..3163860 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag LVJ90_RS15075 Protein ID WP_003414602.1
Coordinates 3163597..3163860 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag LVJ90_RS15070 Protein ID WP_003414599.1
Coordinates 3163312..3163593 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS15045 (LVJ90_15045) 3158935..3159792 - 858 WP_003899513.1 type I methionyl aminopeptidase -
LVJ90_RS15050 (LVJ90_15050) 3159834..3160418 - 585 WP_003899514.1 DUF1707 domain-containing protein -
LVJ90_RS15055 (LVJ90_15055) 3160522..3160770 + 249 WP_003913411.1 antitoxin VapB23 -
LVJ90_RS15060 (LVJ90_15060) 3160767..3161147 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS15065 (LVJ90_15065) 3161229..3163040 - 1812 WP_003414596.1 penicillin-binding protein -
LVJ90_RS15070 (LVJ90_15070) 3163312..3163593 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
LVJ90_RS15075 (LVJ90_15075) 3163597..3163860 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ90_RS15080 (LVJ90_15080) 3164233..3165087 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
LVJ90_RS15085 (LVJ90_15085) 3165143..3166306 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LVJ90_RS15090 (LVJ90_15090) 3166323..3167537 - 1215 WP_003899518.1 zinc metalloprotease Rip -
LVJ90_RS15095 (LVJ90_15095) 3167545..3168786 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T228555 WP_003414602.1 NZ_CP089611:3163597-3163860 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T228555 NZ_CP124322:2010744-2010995 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT228555 WP_003414599.1 NZ_CP089611:3163312-3163593 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT228555 NZ_CP124322:2010992-2011246 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References