Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3119486..3121260 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag LVJ90_RS14855 Protein ID WP_003414409.1
Coordinates 3119486..3120370 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag LVJ90_RS14860 Protein ID WP_003414414.1
Coordinates 3120373..3121260 (-) Length 296 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS14835 (LVJ90_14840) 3114741..3115115 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
LVJ90_RS14840 (LVJ90_14845) 3115112..3117550 - 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
LVJ90_RS14845 (LVJ90_14850) 3117547..3118335 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
LVJ90_RS14850 (LVJ90_14855) 3118669..3119214 - 546 WP_003913758.1 DUF1802 family protein -
LVJ90_RS14855 (LVJ90_14860) 3119486..3120370 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LVJ90_RS14860 (LVJ90_14865) 3120373..3121260 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LVJ90_RS14865 (LVJ90_14870) 3121565..3122110 - 546 WP_003899500.1 DUF1802 family protein -
LVJ90_RS14870 (LVJ90_14875) 3122107..3122376 - 270 WP_003912856.1 DUF2277 family protein -
LVJ90_RS14875 (LVJ90_14880) 3122397..3122789 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS14880 (LVJ90_14885) 3122786..3123001 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ90_RS14885 (LVJ90_14890) 3123048..3123797 + 750 WP_003414497.1 enoyl-CoA hydratase -
LVJ90_RS14890 (LVJ90_14895) 3123876..3124958 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T228553 WP_003414409.1 NZ_CP089611:c3120370-3119486 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

>T228553 NZ_CP124322:c825577-825200 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT228553 WP_003414414.1 NZ_CP089611:c3121260-3120373 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp

>AT228553 NZ_CP124322:c826034-825654 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6Y56


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References