Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917309..2918023 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ90_RS13680 Protein ID WP_003413460.1
Coordinates 2917583..2918023 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ90_RS13675 Protein ID WP_003413456.1
Coordinates 2917309..2917596 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS13640 (LVJ90_13640) 2912731..2912976 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ90_RS13645 (LVJ90_13645) 2912973..2913377 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS13650 (LVJ90_13650) 2913594..2914214 + 621 WP_003413441.1 DUF4178 domain-containing protein -
LVJ90_RS13655 (LVJ90_13655) 2914225..2914719 + 495 WP_003413444.1 DUF2617 family protein -
LVJ90_RS13660 (LVJ90_13660) 2914716..2915147 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ90_RS13665 (LVJ90_13665) 2915172..2915630 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ90_RS13670 (LVJ90_13670) 2915627..2917198 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LVJ90_RS13675 (LVJ90_13675) 2917309..2917596 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ90_RS13680 (LVJ90_13680) 2917583..2918023 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ90_RS13685 (LVJ90_13685) 2918044..2918799 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ90_RS13690 (LVJ90_13690) 2918932..2919528 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ90_RS13695 (LVJ90_13695) 2919536..2920381 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ90_RS13700 (LVJ90_13700) 2920410..2921309 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ90_RS13705 (LVJ90_13705) 2921437..2922111 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T228548 WP_003413460.1 NZ_CP089611:2917583-2918023 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T228548 NZ_CP124322:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT228548 WP_003413456.1 NZ_CP089611:2917309-2917596 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT228548 NZ_CP124322:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References