Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2368541..2369236 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ90_RS11055 Protein ID WP_003410811.1
Coordinates 2368541..2368975 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ90_RS11060 Protein ID WP_003410814.1
Coordinates 2368982..2369236 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS11040 (LVJ90_11050) 2364730..2366268 + 1539 WP_023637436.1 HNH endonuclease signature motif containing protein -
LVJ90_RS11045 (LVJ90_11055) 2366467..2368137 + 1671 Protein_2184 SNF2 helicase-associated domain-containing protein -
LVJ90_RS11050 (LVJ90_11060) 2368140..2368562 + 423 Protein_2185 SWIM zinc finger family protein -
LVJ90_RS11055 (LVJ90_11065) 2368541..2368975 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ90_RS11060 (LVJ90_11070) 2368982..2369236 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ90_RS11065 (LVJ90_11075) 2369252..2369509 - 258 WP_003410816.1 hypothetical protein -
LVJ90_RS11070 (LVJ90_11080) 2370456..2370752 + 297 WP_003410820.1 PE family protein -
LVJ90_RS11075 (LVJ90_11085) 2370808..2371539 + 732 WP_003900467.1 PPE family protein -
LVJ90_RS11080 (LVJ90_11090) 2372079..2372825 - 747 WP_003899174.1 proteasome subunit alpha -
LVJ90_RS11085 (LVJ90_11095) 2372822..2373697 - 876 WP_003411023.1 proteasome subunit beta -
LVJ90_RS11090 (LVJ90_11100) 2373694..2373888 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T228541 WP_003410811.1 NZ_CP089611:c2368975-2368541 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T228541 NZ_CP124320:c3213898-3213644 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT228541 WP_003410814.1 NZ_CP089611:c2369236-2368982 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT228541 NZ_CP124320:c3214146-3213895 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References