Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2204846..2205390 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag LVJ90_RS10280 Protein ID WP_003409896.1
Coordinates 2204846..2205142 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag LVJ90_RS10285 Protein ID WP_003409899.1
Coordinates 2205139..2205390 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS10225 (LVJ90_10235) 2199879..2200229 - 351 WP_003899096.1 hypothetical protein -
LVJ90_RS10230 (LVJ90_10240) 2200240..2201142 - 903 WP_003899097.1 hypothetical protein -
LVJ90_RS10235 (LVJ90_10245) 2201163..2201354 - 192 WP_003409876.1 hypothetical protein -
LVJ90_RS10240 (LVJ90_10250) 2201355..2201651 - 297 WP_003409877.1 hypothetical protein -
LVJ90_RS10245 (LVJ90_10255) 2201891..2202106 + 216 WP_003409878.1 antitoxin -
LVJ90_RS10250 (LVJ90_10260) 2202103..2202414 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS10255 (LVJ90_10265) 2202388..2202909 - 522 WP_003904745.1 hypothetical protein -
LVJ90_RS10260 (LVJ90_10270) 2202884..2203261 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
LVJ90_RS10265 (LVJ90_10275) 2203303..2203752 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
LVJ90_RS10270 (LVJ90_10280) 2203749..2204294 + 546 WP_003899098.1 SecB-like chaperone -
LVJ90_RS10275 (LVJ90_10285) 2204183..2204797 - 615 WP_003901296.1 hypothetical protein -
LVJ90_RS10280 (LVJ90_10290) 2204846..2205142 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ90_RS10285 (LVJ90_10295) 2205139..2205390 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LVJ90_RS10290 (LVJ90_10300) 2205377..2205871 + 495 WP_003899099.1 hypothetical protein -
LVJ90_RS10295 (LVJ90_10305) 2206031..2206438 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS10300 (LVJ90_10310) 2206442..2206714 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ90_RS10305 (LVJ90_10315) 2206747..2207967 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
LVJ90_RS10310 (LVJ90_10320) 2208866..2209663 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T228534 WP_003409896.1 NZ_CP089611:c2205142-2204846 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T228534 NZ_CP124320:1378495-1379415 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT228534 WP_003409899.1 NZ_CP089611:c2205390-2205139 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT228534 NZ_CP124320:1377726-1378508 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References