Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574707..1575362 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag LVJ90_RS07460 Protein ID WP_003898861.1
Coordinates 1574707..1575108 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LVJ90_RS07465 Protein ID WP_003407272.1
Coordinates 1575105..1575362 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS07445 (LVJ90_07445) 1570180..1571565 - 1386 WP_003407260.1 cytochrome P450 -
LVJ90_RS07450 (LVJ90_07450) 1571643..1572677 + 1035 WP_003407264.1 AraC family transcriptional regulator -
LVJ90_RS07455 (LVJ90_07455) 1572723..1574452 - 1730 Protein_1468 PE family protein -
LVJ90_RS07460 (LVJ90_07460) 1574707..1575108 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ90_RS07465 (LVJ90_07465) 1575105..1575362 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
LVJ90_RS07470 (LVJ90_07470) 1575445..1576404 - 960 WP_003407276.1 alpha/beta hydrolase -
LVJ90_RS07475 (LVJ90_07475) 1576429..1577391 - 963 WP_003407279.1 alpha/beta hydrolase -
LVJ90_RS07480 (LVJ90_07480) 1577390..1578127 + 738 WP_031647000.1 lysoplasmalogenase -
LVJ90_RS07485 (LVJ90_07485) 1578208..1580175 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T228527 WP_003898861.1 NZ_CP089611:c1575108-1574707 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T228527 NZ_CP124320:256112-256219 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT228527 WP_003407272.1 NZ_CP089611:c1575362-1575105 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT228527 NZ_CP124320:c256063-255998 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References