Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1027642..1028615 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag LVJ90_RS04890 Protein ID WP_003404756.1
Coordinates 1028115..1028615 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag LVJ90_RS04885 Protein ID WP_003898647.1
Coordinates 1027642..1028118 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS04865 (LVJ90_04860) 1023489..1024760 - 1272 WP_003404747.1 PPE family protein -
LVJ90_RS04870 (LVJ90_04865) 1024775..1025074 - 300 WP_003404748.1 PE family protein -
LVJ90_RS04875 (LVJ90_04870) 1025518..1027299 + 1782 WP_003404749.1 BCCT family transporter -
LVJ90_RS04880 (LVJ90_04875) 1027299..1027553 + 255 WP_003898646.1 hypothetical protein -
LVJ90_RS04885 (LVJ90_04880) 1027642..1028118 + 477 WP_003898647.1 DUF1778 domain-containing protein Antitoxin
LVJ90_RS04890 (LVJ90_04885) 1028115..1028615 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
LVJ90_RS04900 (LVJ90_04895) 1028928..1030247 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
LVJ90_RS04905 (LVJ90_04900) 1030535..1031116 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
LVJ90_RS04910 (LVJ90_04905) 1031116..1032768 + 1653 WP_003404761.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T228520 WP_003404756.1 NZ_CP089611:1028115-1028615 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T228520 NZ_CP124220:c3359936-3359834 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT228520 WP_003898647.1 NZ_CP089611:1027642-1028118 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT228520 NZ_CP124220:3359827-3359972 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB A5U0V8

References