Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 757822..758455 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag LVJ90_RS03490 Protein ID WP_003403365.1
Coordinates 757822..758205 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag LVJ90_RS03495 Protein ID WP_003403368.1
Coordinates 758300..758455 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS03465 (LVJ90_03460) 753114..753650 + 537 WP_003403341.1 50S ribosomal protein L10 -
LVJ90_RS03470 (LVJ90_03465) 753687..754079 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
LVJ90_RS03475 (LVJ90_03470) 754072..754767 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
LVJ90_RS03480 (LVJ90_03475) 754838..756343 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
LVJ90_RS03485 (LVJ90_03480) 756424..757434 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ90_RS03490 (LVJ90_03485) 757822..758205 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
LVJ90_RS03495 (LVJ90_03490) 758300..758455 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ90_RS03500 (LVJ90_03495) 758531..759247 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ90_RS03505 (LVJ90_03500) 759523..759831 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ90_RS03510 (LVJ90_03505) 759818..760063 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ90_RS03515 (LVJ90_03510) 760173..760610 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS03520 (LVJ90_03515) 760607..760861 - 255 WP_003911263.1 antitoxin VapB7 -
LVJ90_RS03525 (LVJ90_03520) 760975..763338 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T228514 WP_003403365.1 NZ_CP089611:c758205-757822 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T228514 NZ_CP124220:583648-583998 [Klebsiella pneumoniae]
ATGTGGACCGTACTTTTTAGCCAACGATTTGATGATTGGCTAAGCGAACAGGATGACGCGCTTCAGGAAAAAGTGCTGGC
AGATTTGGGCAAGTTACAGGTGTATGGCCCCGAGCTGCCAAGGCCCTATGCGGATACGCTCAAAGGCTCGCGATACAAGA
ATATGAAGGAGCTGCGTATTCAGTTTTCCGGGCAGCCGATACGCGCATTTTATGCCTTTGATCCGATTCGCCGGGCGATT
GTGCTTTGTGCCGGATATAAGAGCAATGACAAACGATTTTATGAAAAACTGATCCGTATTGCTGAAGATGAATTTGCCGC
GCACCTGCAAAATCTGGAGATAAACCAATGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT228514 WP_003403368.1 NZ_CP089611:c758455-758300 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT228514 NZ_CP124220:583995-584294 [Klebsiella pneumoniae]
ATGAGAACACTCGACGATGTGATTGCCGCACGCTCTCCTGAAAGCCAGGCCAGAATCAAAGAGATGTCTGATGAAATGAT
CCTTGAGGTCGGCTTACAGATGATGCGTGAAGAGCTTCAGCTTTCGCAGAAGTATGTGGCGGAAATGATGGGCGTTAGCC
AGCCAGCCATCACCCAGCTGGAGCAGCGGGGTAATGACCTGAAACTGGCCACACTGAAGCGCTATATTGAAGCAATGGGC
GGCAAGCTTAGCTTGGATGTCGAACTACCCACTGGGAAGCGCATCGCGTTTCATATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References