Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715087..715712 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ90_RS03270 Protein ID WP_003403218.1
Coordinates 715311..715712 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ90_RS03265 Protein ID WP_003403213.1
Coordinates 715087..715314 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS03240 (LVJ90_03235) 710266..710487 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ90_RS03245 (LVJ90_03240) 710629..711234 + 606 WP_003898526.1 hypothetical protein -
LVJ90_RS03250 (LVJ90_03245) 711253..713820 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
LVJ90_RS03255 (LVJ90_03250) 713904..714653 + 750 WP_003898528.1 hypothetical protein -
LVJ90_RS03260 (LVJ90_03255) 714650..714892 + 243 WP_003403210.1 hypothetical protein -
LVJ90_RS03265 (LVJ90_03260) 715087..715314 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ90_RS03270 (LVJ90_03265) 715311..715712 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ90_RS03275 (LVJ90_03270) 715841..715924 + 84 Protein_649 galactose-1-phosphate uridylyltransferase -
LVJ90_RS03280 (LVJ90_03275) 715943..717024 + 1082 Protein_650 galactose-1-phosphate uridylyltransferase -
LVJ90_RS03285 (LVJ90_03280) 717021..718112 + 1092 WP_003906403.1 galactokinase -
LVJ90_RS03290 (LVJ90_03285) 718507..719571 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ90_RS03295 (LVJ90_03290) 719675..720622 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T228511 WP_003403218.1 NZ_CP089611:715311-715712 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T228511 NZ_CP124219:1299146-1299490 [Pseudomonas sp. P13]
ATGCGTACCCTATTTTTTGAAACGACTACATTCACCGCCACGGTTGGCCATTACCTGACTGATGATGAGTATCGCCTGCT
TCAGTCCTATATGCTGGAGCATCCAGAGGTCGGTGACGTCATGCCACGTACCGGCGGCTTTCGTAAGCTGCGCTGGTTTG
ATGGCCGTCGTGGCAAAGGGAAGCGCGGTGGGTTGCGAGTTATTTATTATTGGCTCATGAATGATCGTCAGTTTTGGATG
TTCGCGATTTATGACAAGGACGAGTTGGTAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAGCGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT228511 WP_003403213.1 NZ_CP089611:715087-715314 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT228511 NZ_CP124219:1299487-1299801 [Pseudomonas sp. P13]
ATGAAAAAGCGCGATCTGTTTGCCGAGATGATGCAAGGCGTGGAGGAGATGGCCGCTCACCGCGAGGGCAAGATTACCCT
TCGCCACATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCGGCCCAGGAAATCGTGGCTTTGCGCGACAAGCTCCACA
TGTCCCAAGCCGTTTTCGCCAAGAGCATCAGGACCAGTCCAGGTACCCTTAGAAATTGGGAGCAGGAAAAATCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAACTGGTCGAGAAGTTTCCAGACATGGTTGAACGGCTTGGCGCTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References