Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707549..708192 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ90_RS03220 Protein ID WP_003403187.1
Coordinates 707791..708192 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ90_RS03215 Protein ID WP_003403184.1
Coordinates 707549..707794 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS03180 (LVJ90_03175) 702829..703359 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ90_RS03185 (LVJ90_03180) 703343..704038 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ90_RS03190 (LVJ90_03185) 704161..704472 + 312 WP_003403164.1 hypothetical protein -
LVJ90_RS03195 (LVJ90_03190) 704544..705494 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ90_RS03200 (LVJ90_03195) 705735..706319 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ90_RS03205 (LVJ90_03200) 706321..707031 + 711 Protein_635 IS607 family element RNA-guided endonuclease TnpB -
LVJ90_RS03210 (LVJ90_03205) 707034..707504 + 471 WP_003898523.1 hypothetical protein -
LVJ90_RS03215 (LVJ90_03210) 707549..707794 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ90_RS03220 (LVJ90_03215) 707791..708192 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ90_RS03225 (LVJ90_03220) 708183..708362 + 180 Protein_639 hypothetical protein -
LVJ90_RS03230 (LVJ90_03225) 708780..708977 - 198 WP_003403191.1 hypothetical protein -
LVJ90_RS03235 (LVJ90_03230) 709057..710214 - 1158 WP_003898524.1 hypothetical protein -
LVJ90_RS03240 (LVJ90_03235) 710266..710487 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ90_RS03245 (LVJ90_03240) 710629..711234 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228510 WP_003403187.1 NZ_CP089611:707791-708192 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228510 NZ_CP124123:39748-40272 [Enterobacter hormaechei]
GTGGCCAACCTGACCATTGAGATGTTTTCAGAAGAGGCTGTATATGATTTCTCATGCTTCGACTGCGGAGAAACGTCTCT
CAATGATTTTCTTAACAATCGCCTCGCCCAGCAACACAGCGGGCGTATATTACGCGGATATCTGCTTCTGACGAGAGATC
CGATACCGAAAGTGATGGGGTTTTACACGTTGTCCGGGAGCTGCTTTGCAAGAAACACGCTTCCTTCCAACACTCAACAG
CGTAAAGTCCCCTATTCCGACGCCCCAAGCGTTACGCTCGGTCGTCTGGCAATAGACAAAAGTATCCAGCGACAAGGGTA
TGGGGAAACGCTGGTGGCACATGCGATGAAAGTGGTATACCGGGCTTCCCTGGCCGTTGGGATCTACGCTTTGTTTGTTG
ACGCCAAAAATGAGAATGCGATGCGGTTTTATAAGCAGTTAGGCTTTACCCCTCTTACGGGTGATAACGCCAATTCGCTG
TTCTATCCCACAAAAGGCATTGAGAAGTTGTTTGGTGGAAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228510 WP_003403184.1 NZ_CP089611:707549-707794 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228510 NZ_CP124123:39475-39744 [Enterobacter hormaechei]
ATGTCAGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACAATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGTCGCC
TGATTCTTAGCGAAGAGTCATGGAATATAGTGATGGATGCCATCAGTAACCCGCCTGCACCGAATGATAGGCTGAAACGA
GCTGCCGAGCGTCTACAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References