Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 699144..699790 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag LVJ90_RS03150 Protein ID WP_003403122.1
Coordinates 699144..699536 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag LVJ90_RS03155 Protein ID WP_003403125.1
Coordinates 699533..699790 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS03135 (LVJ90_03130) 694805..696332 + 1528 Protein_621 virulence factor Mce family protein -
LVJ90_RS03140 (LVJ90_03135) 696395..697537 + 1143 WP_003911253.1 virulence factor Mce family protein -
LVJ90_RS03145 (LVJ90_03140) 697542..699092 + 1551 WP_003403119.1 MlaD family protein -
LVJ90_RS03150 (LVJ90_03145) 699144..699536 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
LVJ90_RS03155 (LVJ90_03150) 699533..699790 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
LVJ90_RS03160 (LVJ90_03155) 699973..701208 - 1236 WP_003403128.1 ATP-binding protein -
LVJ90_RS03165 (LVJ90_03160) 701459..701872 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
LVJ90_RS03170 (LVJ90_03165) 701869..702105 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
LVJ90_RS03175 (LVJ90_03170) 702209..702715 - 507 WP_003900973.1 two component system sensor kinase HK1 -
LVJ90_RS03180 (LVJ90_03175) 702829..703359 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ90_RS03185 (LVJ90_03180) 703343..704038 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ90_RS03190 (LVJ90_03185) 704161..704472 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T228508 WP_003403122.1 NZ_CP089611:c699536-699144 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T228508 NZ_CP124122:c47542-47057 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGAGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATGTTTCATTCCGTGGAAAAGGGCTCGGAGCTGATTT
ACTGCATGATGCAGTTCTGCGTTGTTACCGTGTAGCTGAAAATATTGGAGTCCGTGCCATTATGGTTCATGCACTGACTG
AAGTGGCCAAAAGCTTTTATCTTCATCATGGTTTTAAGGCATCACAAACCCAGGAGCGGACTTTGTTTCTCAAACTACCA
CAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT228508 WP_003403125.1 NZ_CP089611:c699790-699533 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT228508 NZ_CP124122:c47796-47530 [Enterobacter hormaechei]
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAGGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References