Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 447212..448223 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LVJ90_RS01945 Protein ID WP_003401859.1
Coordinates 447212..447805 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ90_RS01950 Protein ID WP_003401860.1
Coordinates 447834..448223 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS01925 (LVJ90_01925) 442861..444243 + 1383 WP_003898415.1 magnesium transporter -
LVJ90_RS01930 (LVJ90_01930) 444255..445289 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ90_RS01935 (LVJ90_01935) 445385..446068 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ90_RS01940 (LVJ90_01940) 446057..447187 - 1131 WP_003900130.1 glycoside hydrolase family 76 protein -
LVJ90_RS01945 (LVJ90_01945) 447212..447805 - 594 WP_003401859.1 zeta toxin family protein Toxin
LVJ90_RS01950 (LVJ90_01950) 447834..448223 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ90_RS01955 (LVJ90_01955) 448304..449515 - 1212 WP_003900131.1 VWA domain-containing protein -
LVJ90_RS01960 (LVJ90_01960) 449521..450123 - 603 WP_003898417.1 SRPBCC family protein -
LVJ90_RS01965 (LVJ90_01965) 450137..451033 - 897 WP_003898418.1 MoxR family ATPase -
LVJ90_RS01970 (LVJ90_01970) 451030..451623 - 594 WP_003900132.1 NTP transferase domain-containing protein -
LVJ90_RS01975 (LVJ90_01975) 451620..452375 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T228505 WP_003401859.1 NZ_CP089611:c447805-447212 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T228505 NZ_CP124121:3562969-3563268 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT228505 WP_003401860.1 NZ_CP089611:c448223-447834 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT228505 NZ_CP124121:3563279-3563644 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References