Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366846..367489 Replicon chromosome
Accession NZ_CP089611
Organism Mycobacterium tuberculosis strain I0004240-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ90_RS01595 Protein ID WP_003401566.1
Coordinates 367064..367489 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ90_RS01590 Protein ID WP_003401563.1
Coordinates 366846..367067 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ90_RS01565 (LVJ90_01565) 361974..362777 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ90_RS01570 (LVJ90_01570) 362787..364184 - 1398 WP_003401544.1 sulfatase -
LVJ90_RS01575 (LVJ90_01575) 364363..366129 + 1767 WP_031648214.1 PE family protein -
LVJ90_RS01580 (LVJ90_01580) 366272..366499 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ90_RS01585 (LVJ90_01585) 366496..366798 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ90_RS01590 (LVJ90_01590) 366846..367067 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ90_RS01595 (LVJ90_01595) 367064..367489 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ90_RS01600 (LVJ90_01600) 367625..368257 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ90_RS01605 (LVJ90_01605) 368254..369162 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ90_RS01610 (LVJ90_01610) 369170..369760 - 591 WP_229298012.1 hypothetical protein -
LVJ90_RS01615 (LVJ90_01615) 369753..369803 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228504 WP_003401566.1 NZ_CP089611:367064-367489 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228504 NZ_CP124121:c2721613-2721510 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228504 WP_003401563.1 NZ_CP089611:366846-367067 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228504 NZ_CP124121:2721505-2721706 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References