Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3781127..3781656 | Replicon | chromosome |
| Accession | NZ_CP089610 | ||
| Organism | Mycobacterium tuberculosis strain I0004290-8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ91_RS17790 | Protein ID | WP_003417760.1 |
| Coordinates | 3781399..3781656 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ91_RS17785 | Protein ID | WP_003417757.1 |
| Coordinates | 3781127..3781402 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ91_RS17750 (LVJ91_17760) | 3777700..3778389 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ91_RS17755 (LVJ91_17765) | 3778576..3778947 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ91_RS17760 (LVJ91_17770) | 3778845..3779063 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ91_RS17765 (LVJ91_17775) | 3779090..3779350 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ91_RS17770 (LVJ91_17780) | 3779465..3779854 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ91_RS17775 (LVJ91_17785) | 3779868..3780161 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ91_RS17780 (LVJ91_17790) | 3780158..3781003 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ91_RS17785 (LVJ91_17795) | 3781127..3781402 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ91_RS17790 (LVJ91_17800) | 3781399..3781656 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ91_RS17795 (LVJ91_17805) | 3781698..3782888 | + | 1191 | WP_012054356.1 | NADH:flavin oxidoreductase | - |
| LVJ91_RS17800 (LVJ91_17810) | 3783005..3783373 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ91_RS17805 (LVJ91_17815) | 3783370..3783921 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ91_RS17810 (LVJ91_17820) | 3783928..3784509 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ91_RS17815 (LVJ91_17825) | 3784490..3784858 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ91_RS17820 (LVJ91_17830) | 3784836..3785228 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T228498 WP_003417760.1 NZ_CP089610:3781399-3781656 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T228498 NZ_CP123994:513270-513620 [Bacillus inaquosorum]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT228498 WP_003417757.1 NZ_CP089610:3781127-3781402 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT228498 NZ_CP123994:512984-513265 [Bacillus inaquosorum]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|