Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3715547..3716221 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ91_RS17590 Protein ID WP_003417282.1
Coordinates 3715547..3715975 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ91_RS17595 Protein ID WP_003417286.1
Coordinates 3715979..3716221 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS17565 (LVJ91_17575) 3711369..3711770 - 402 WP_003417264.1 cytidine deaminase -
LVJ91_RS17570 (LVJ91_17580) 3712007..3712345 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ91_RS17575 (LVJ91_17585) 3712342..3712776 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ91_RS17580 (LVJ91_17590) 3712905..3714677 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ91_RS17585 (LVJ91_17595) 3714677..3715468 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ91_RS17590 (LVJ91_17600) 3715547..3715975 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ91_RS17595 (LVJ91_17605) 3715979..3716221 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ91_RS17600 (LVJ91_17610) 3716343..3716957 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ91_RS17605 (LVJ91_17615) 3716954..3717619 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ91_RS17610 (LVJ91_17620) 3717620..3718153 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ91_RS17615 (LVJ91_17625) 3718150..3718524 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228497 WP_003417282.1 NZ_CP089610:c3715975-3715547 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228497 NZ_CP123993:3089976-3090155 [Acinetobacter baumannii]
ATGAGCTTCAACGAGTTTAAACGATGGCTAATTGCACAGGGAGTTATCTTTGTGCGTAAAGGTAAGGGATCACATATGAT
TATTGAATTTAACGGTAAGAAGACTGTTTTCCCTAACCACGGGAAAAAAGAAATTCCTGAAGGCACTCGTTTAAAGATCA
AAAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228497 WP_003417286.1 NZ_CP089610:c3716221-3715979 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228497 NZ_CP123993:3090241-3090654 [Acinetobacter baumannii]
ATGAAATGTTATGTCAGTATTCATAGGGAGGGAGAGGCTTTTATAGTCAGCTCAAGTGAACTCCCTGAACTAAATAGTGT
AGGCTATACTCTAGAAGAAGCTTTATCAGAAGCTTTGGATGGTATAGAAACAGTATTCGAAATTTATATGGATGAGCGTA
AAGCCATCCCATTACCATCGAAAGGTAAGAAAGGTGAATATGTAGTTCATCTTCCAGTTCGAGTCGCTGCTAAGGTACGT
TTATATAATGAGATGATCTCACAAAATGTTACTAAAGCTGAATTAGCTCGTCGCTTGGGGTGGTTACAGAAGCAAGCCGA
TCGTTTGCTTTCTTTAAAGCATTCAACAAAACTAGAATCGATTGAAAGTGCCTTCCAAGCATTAGGCAAGGATCTCGATA
TAGTTATCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References