228492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3143104..3144878 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag LVJ91_RS14965 Protein ID WP_003414409.1
Coordinates 3143104..3143988 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag LVJ91_RS14970 Protein ID WP_003414414.1
Coordinates 3143991..3144878 (-) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS14945 (LVJ91_14955) 3138359..3138733 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
LVJ91_RS14950 (LVJ91_14960) 3138730..3141168 - 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
LVJ91_RS14955 (LVJ91_14965) 3141165..3141953 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
LVJ91_RS14960 (LVJ91_14970) 3142287..3142832 - 546 WP_003913758.1 DUF1802 family protein -
LVJ91_RS14965 (LVJ91_14975) 3143104..3143988 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LVJ91_RS14970 (LVJ91_14980) 3143991..3144878 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LVJ91_RS14975 (LVJ91_14985) 3145183..3145728 - 546 WP_003899500.1 DUF1802 family protein -
LVJ91_RS14980 (LVJ91_14990) 3145725..3145994 - 270 WP_003414489.1 DUF2277 family protein -
LVJ91_RS14985 (LVJ91_14995) 3146015..3146407 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
LVJ91_RS14990 (LVJ91_15000) 3146404..3146619 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ91_RS14995 (LVJ91_15005) 3146666..3147415 + 750 WP_003414497.1 enoyl-CoA hydratase -
LVJ91_RS15000 (LVJ91_15010) 3147494..3148574 - 1081 Protein_2961 ABC transporter ATP-binding protein -
LVJ91_RS15005 (LVJ91_15015) 3148567..3149877 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T228492 WP_003414409.1 NZ_CP089610:c3143988-3143104 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

>T228492 NZ_CP123990:c5694373-5693513 [Variovorax paradoxus]
ATGAGCGGCAATCTCGCGGCCTCGGTAAGAGCCCGCTTGAAACAGCATGCCGATGCCACAAAGCAGGATTTCAACCTCAT
CCTGACCTACTATGGATTGGAGCGGTTGCTGTATCGGCTGTCGATCTCACCGCATGCCACCAACTACCTGCTCAAGGGCG
CGCTGCTGTTTTCGCTGTGGTATGACCACCCCCATCGGCCGACGCGGGATGCGGACCTGTTGGGCTTCGGCCCGGACGAT
ACCGTCACCGCGGTGGCAGCGTTCCGCGAGGTCTGCCAGATCGAGGTGGAGGATGGCGTCGCTTTCGACCCTGCATCTGT
CAAGGGTTCGGTGATCCGCAAAGAGGCAGGCTATGGCGGCGTCCGGGTCGAACTGCAGGCGAAGTTGGATGGCGCACGCA
TCGCGCTGCAAGTCGACATCGGTTTTGGCGATGCGGTCACCCCAGCGCCCGAATCGGTGAGCTACCCGGTGCTGCTCGCA
GACCTGCCCGCCCCGCAACTGCGCTGCTATCCGAAATACACCGTGATCGCCGAGAAGTTGCACGCAGTGTGCCTTCTGGG
CATGGCGAATACCCGCCTGAAGGACTACTTCGATCTCTGGGTTCTGCTGGCCGACCATGCCCTGGAAACCGCAGAACTGC
GCCGCGCCGTCAAGGCCACATTTGAACGAAGGAAACTCGCGTTCCCCGCCACCATCCCTTCTGGGTTGAGCGATGCATTC
GTGCAGGATGCTGCAAAGCAAAGTCAATGGACCGCCTTCCTGAAAAAGAACCGTCTCGATGCGCTGGACCTCGCCGAAGT
CGTGGCGCGGTTGCGCGGCGAGTTCGAGAAACTTCTGGTGTCGCACTCCACGGACGCCTGA

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT228492 WP_003414414.1 NZ_CP089610:c3144878-3143991 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp

>AT228492 NZ_CP123990:c5694981-5694370 [Variovorax paradoxus]
ATGGGCTCAGATTCCGCGCTCGAACAAGCCGTGCTCGCACTCGCGGAGCGCCGACCACTGCTGCGCGCGCGCGAACTGGC
CGAGCAGGGCCTGCCCACGGTAGTGCTCAGCCGACTGGTTTCCGCCGGCAAGCTTGATCGCGTCGCCCGCGGCGTCTACA
CCTTGCCGGACCGCGCGCTGAGTGAGCACCGGTCTCTGGCCGAAGTAGCCTTGCGCGTGCCGCGGGGCGTGGTATGCCTG
CTATCGGCGCTGCGCGTCCATGGCATCGGCACGCAGGCGCCGTTCGAAGTCTGGATCGCGATTCCTCGTCACTCGCCTAG
ACCCCGGCTCGACCGCCCTGCCCTGCGCGTCGTGCGCATGTCGGGGACGGCTCTGACCGAAGGCATCGAACCGATGGAGA
TCGATGGCGTGAAGGTCCCGGTTTTCAATGCGGCCAAGACGGTGGCCGACTGCTTCAAGTATCGCAACAAGATCGGTCTG
GACGTGGCTCTCGAAGCGCTGCGCGATGGTTGGTCTCAACGCAAGCTGACGATCGATGCGCTCTGGCACTACGCCACCGT
GGATCGCGTCGCGAATGTCATGCGGCCCTATCTGGAAAGCGTCACAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References