Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2237487..2238385 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LVJ91_RS10460 Protein ID WP_003410001.1
Coordinates 2237487..2238047 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LVJ91_RS10465 Protein ID WP_003410003.1
Coordinates 2238044..2238385 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS10430 (LVJ91_10445) 2232656..2233309 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ91_RS10435 (LVJ91_10450) 2233424..2233654 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ91_RS10440 (LVJ91_10455) 2233739..2234650 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ91_RS10445 (LVJ91_10460) 2234759..2235358 + 600 WP_003409989.1 L-lysine exporter -
LVJ91_RS10450 (LVJ91_10465) 2235774..2236202 + 429 WP_003906713.1 cellulose-binding protein -
LVJ91_RS10455 (LVJ91_10470) 2236428..2236967 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LVJ91_RS10460 (LVJ91_10475) 2237487..2238047 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LVJ91_RS10465 (LVJ91_10480) 2238044..2238385 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LVJ91_RS10470 (LVJ91_10485) 2238471..2238728 + 258 WP_003410006.1 hypothetical protein -
LVJ91_RS10475 (LVJ91_10490) 2238629..2238964 - 336 WP_003410009.1 dehydrogenase -
LVJ91_RS10480 (LVJ91_10495) 2239053..2239397 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LVJ91_RS10485 (LVJ91_10500) 2239391..2239639 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LVJ91_RS10490 (LVJ91_10505) 2239739..2242054 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LVJ91_RS10495 (LVJ91_10510) 2242051..2242323 - 273 WP_003410017.1 DUF1490 family protein -
LVJ91_RS10500 (LVJ91_10515) 2242376..2242732 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T228475 WP_003410001.1 NZ_CP089610:c2238047-2237487 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T228475 NZ_CP123963:c4170285-4170112 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT228475 WP_003410003.1 NZ_CP089610:c2238385-2238044 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT228475 NZ_CP123963:c4170609-4170313 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References