Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2208428..2208972 | Replicon | chromosome |
| Accession | NZ_CP089610 | ||
| Organism | Mycobacterium tuberculosis strain I0004290-8 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LVJ91_RS10295 | Protein ID | WP_003409896.1 |
| Coordinates | 2208428..2208724 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | LVJ91_RS10300 | Protein ID | WP_003409899.1 |
| Coordinates | 2208721..2208972 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ91_RS10240 (LVJ91_10255) | 2203461..2203811 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ91_RS10245 (LVJ91_10260) | 2203822..2204724 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ91_RS10250 (LVJ91_10265) | 2204745..2204936 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ91_RS10255 (LVJ91_10270) | 2204937..2205233 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ91_RS10260 (LVJ91_10275) | 2205473..2205688 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ91_RS10265 (LVJ91_10280) | 2205685..2205996 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ91_RS10270 (LVJ91_10285) | 2205970..2206491 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ91_RS10275 (LVJ91_10290) | 2206466..2206843 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LVJ91_RS10280 (LVJ91_10295) | 2206885..2207334 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LVJ91_RS10285 (LVJ91_10300) | 2207331..2207876 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ91_RS10290 (LVJ91_10305) | 2207765..2208379 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ91_RS10295 (LVJ91_10310) | 2208428..2208724 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ91_RS10300 (LVJ91_10315) | 2208721..2208972 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LVJ91_RS10305 (LVJ91_10320) | 2208959..2209453 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ91_RS10310 (LVJ91_10325) | 2209613..2210020 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ91_RS10315 (LVJ91_10330) | 2210024..2210296 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ91_RS10320 (LVJ91_10335) | 2210329..2211549 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ91_RS10325 (LVJ91_10340) | 2212448..2213245 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T228473 WP_003409896.1 NZ_CP089610:c2208724-2208428 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T228473 NZ_CP123963:c3644435-3644037 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT228473 WP_003409899.1 NZ_CP089610:c2208972-2208721 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT228473 NZ_CP123963:c3644731-3644438 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |