Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756671..757304 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag LVJ91_RS03470 Protein ID WP_003403365.1
Coordinates 756671..757054 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag LVJ91_RS03475 Protein ID WP_003403368.1
Coordinates 757149..757304 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS03445 (LVJ91_03440) 751963..752499 + 537 WP_003403341.1 50S ribosomal protein L10 -
LVJ91_RS03450 (LVJ91_03445) 752536..752928 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
LVJ91_RS03455 (LVJ91_03450) 752921..753616 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
LVJ91_RS03460 (LVJ91_03455) 753687..755192 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
LVJ91_RS03465 (LVJ91_03460) 755273..756283 + 1011 WP_009937374.1 ABC transporter ATP-binding protein -
LVJ91_RS03470 (LVJ91_03465) 756671..757054 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
LVJ91_RS03475 (LVJ91_03470) 757149..757304 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ91_RS03480 (LVJ91_03475) 757380..758096 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ91_RS03485 (LVJ91_03480) 758372..758680 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ91_RS03490 (LVJ91_03485) 758667..758912 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ91_RS03495 (LVJ91_03490) 759022..759459 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
LVJ91_RS03500 (LVJ91_03495) 759456..759710 - 255 WP_003911263.1 antitoxin VapB7 -
LVJ91_RS03505 (LVJ91_03500) 759824..762187 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T228453 WP_003403365.1 NZ_CP089610:c757054-756671 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T228453 NZ_CP123958:1550877-1551266 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT228453 WP_003403368.1 NZ_CP089610:c757304-757149 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT228453 NZ_CP123958:1550616-1550876 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References