Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1022536..1023367 Replicon chromosome
Accession NC_010658
Organism Shigella boydii CDC 3083-94

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag SBBS512_RS07470 Protein ID WP_000854814.1
Coordinates 1022993..1023367 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag SBBS512_RS07465 Protein ID WP_001285585.1
Coordinates 1022536..1022904 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBBS512_RS07430 1018683..1018982 - 300 Protein_1017 IS1 family transposase -
SBBS512_RS07445 1020295..1021125 + 831 WP_039059216.1 DUF945 domain-containing protein -
SBBS512_RS07450 1021207..1021686 + 480 WP_000860059.1 antirestriction protein -
SBBS512_RS07455 1021702..1022178 + 477 WP_012421636.1 RadC family protein -
SBBS512_RS07460 1022241..1022462 + 222 WP_000692323.1 DUF987 domain-containing protein -
SBBS512_RS07465 1022536..1022904 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
SBBS512_RS07470 1022993..1023367 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
SBBS512_RS07475 1023364..1023558 + 195 WP_000988600.1 hypothetical protein -
SBBS512_RS32955 1023571..1023684 + 114 WP_001161660.1 DUF957 domain-containing protein -
SBBS512_RS07485 1024073..1025200 + 1128 WP_001063811.1 IS110-like element ISSso6 family transposase -
SBBS512_RS07490 1025467..1025706 - 240 Protein_1028 nickel/cobalt efflux protein RcnA -
SBBS512_RS07495 1025828..1026100 + 273 WP_000019944.1 Ni(II)/Co(II)-binding transcriptional repressor RcnR -
SBBS512_RS07500 1026323..1027111 + 789 WP_001195636.1 hydroxyethylthiazole kinase -
SBBS512_RS07505 1027108..1027908 + 801 WP_000822274.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1002704..1025200 22496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T22845 WP_000854814.1 NC_010658:1022993-1023367 [Shigella boydii CDC 3083-94]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T22845 NC_010658:1022993-1023367 [Shigella boydii CDC 3083-94]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT22845 WP_001285585.1 NC_010658:1022536-1022904 [Shigella boydii CDC 3083-94]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT22845 NC_010658:1022536-1022904 [Shigella boydii CDC 3083-94]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References