Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 680867..681486 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag LVJ91_RS03065 Protein ID WP_003403047.1
Coordinates 681079..681486 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag LVJ91_RS03060 Protein ID WP_003403039.1
Coordinates 680867..681082 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS03050 (LVJ91_03045) 679395..680153 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
LVJ91_RS03055 (LVJ91_03050) 680282..680773 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
LVJ91_RS03060 (LVJ91_03055) 680867..681082 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
LVJ91_RS03065 (LVJ91_03060) 681079..681486 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
LVJ91_RS03070 (LVJ91_03065) 681546..682232 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
LVJ91_RS03075 (LVJ91_03070) 682386..685019 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T228446 WP_003403047.1 NZ_CP089610:681079-681486 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T228446 NZ_CP123957:4604292-4604480 [Pseudomonas marginalis]
GTGCAAAGCAGGCTATTGATCAAGGAGCTGCAAGAGGCGGGCTGGGTGCTGGATCGGGTCACGGGCAGTCATCATATTTT
TACCCACCGCTATAACCCGTACACGATCCCGGTGCCGCATCCGAAGAAGGATCTGCCCTTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGGCTGTTTCAGTTTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT228446 WP_003403039.1 NZ_CP089610:680867-681082 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT228446 NZ_CP123957:4604492-4604896 [Pseudomonas marginalis]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTCACCGCCACCGGTATCCAGATCCCCGATATTCCAGGCGCAGC
CACTGCCGGGGACAGTTTCGAAGAGGCGTACAACGCTGCTGTGGAAGTCGCGCACATCCTGCTGCAGGAGATCGCCGCGG
AGGGTGGGGTGATTCCGATGCCAACATCGGTGGCCAATCATCACACCCACGAAGACTATGTCGGGATGGGCTGGGGCATG
CTGGAGCTGGACATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTCATCCAGCGCAT
CGATCGCTATGTGCGCGAGCACAAGGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCTTTGGAGAAGTTGGTGCGTT
CTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References