Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366885..367528 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ91_RS01595 Protein ID WP_003401566.1
Coordinates 367103..367528 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ91_RS01590 Protein ID WP_003401563.1
Coordinates 366885..367106 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS01565 (LVJ91_01565) 361984..362787 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ91_RS01570 (LVJ91_01570) 362797..364194 - 1398 WP_003401544.1 sulfatase -
LVJ91_RS01575 (LVJ91_01575) 364373..366148 + 1776 WP_010886074.1 PE family protein -
LVJ91_RS01580 (LVJ91_01580) 366291..366538 + 248 Protein_312 ribbon-helix-helix protein, CopG family -
LVJ91_RS01585 (LVJ91_01585) 366535..366837 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ91_RS01590 (LVJ91_01590) 366885..367106 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ91_RS01595 (LVJ91_01595) 367103..367528 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ91_RS01600 (LVJ91_01600) 367664..368296 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ91_RS01605 (LVJ91_01605) 368293..369201 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ91_RS01610 (LVJ91_01610) 369209..369799 - 591 WP_229298012.1 hypothetical protein -
LVJ91_RS01615 (LVJ91_01615) 369792..369842 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228443 WP_003401566.1 NZ_CP089610:367103-367528 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228443 NZ_CP123957:1193403-1193654 [Pseudomonas marginalis]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAATTGCTCAACGAGCAGATGGCATTTACCTGGCCAGAACTCGTCACGCTGCT
GCGTCGTCTCGGCTACACACAGATTGAGGGGGCTGGAAGCCGGGTCAAGTTCGACATCGGCGATCCGAGCGCAATGATCA
CCTTGCACAAGCCTCATCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228443 WP_003401563.1 NZ_CP089610:366885-367106 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228443 NZ_CP123957:1193651-1194016 [Pseudomonas marginalis]
GTGAACAACCAACTGAAACACAATGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAATTGCCTGTTCGGCAAGAT
CCTGTTCATCAAGGCACTGGTGAGTTACGAAGGCAAAACCGTCGCGGAACTGGACGCCGCGTTTCGCGAGGCGGTGGACG
ACTACCTCGCTACCTGCCAGGCCCTTGGGCAAACACCGGAGAAGCCGTGCAAAGGCTCTTTCAACGTGCGGGTCGGCCAC
GACCTTCATCTTGCCGCCGCCCTTGAAGCGACACGTAAAAAGGTGACCCTGAATGACCTGACGCGCCAGGCGCTGAACGA
ATTCCTGCAACACCACCGAGGGGATTCCTGCCCCGTGACTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References