Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2289061..2290039 Replicon chromosome
Accession NZ_CP089601
Organism Bacillus cereus strain C-1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag LRS65_RS11865 Protein ID WP_257116059.1
Coordinates 2289061..2289798 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID M1PKC2
Locus tag LRS65_RS11870 Protein ID WP_000237819.1
Coordinates 2289911..2290039 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS65_RS11845 (LRS65_11825) 2284702..2285484 + 783 WP_000355673.1 class I SAM-dependent methyltransferase -
LRS65_RS11850 (LRS65_11830) 2285642..2287319 - 1678 Protein_2256 alpha-keto acid decarboxylase family protein -
LRS65_RS11855 (LRS65_11835) 2287436..2287918 + 483 WP_000191889.1 MarR family winged helix-turn-helix transcriptional regulator -
LRS65_RS11860 (LRS65_11840) 2288085..2288822 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
LRS65_RS11865 (LRS65_11845) 2289061..2289798 + 738 WP_257116059.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
LRS65_RS11870 (LRS65_11850) 2289911..2290039 + 129 WP_000237819.1 hypothetical protein Antitoxin
LRS65_RS11875 (LRS65_11855) 2290112..2290288 + 177 WP_000852629.1 stage II sporulation protein SB -
LRS65_RS11880 (LRS65_11860) 2290307..2290696 - 390 WP_025687525.1 YxeA family protein -
LRS65_RS11885 (LRS65_11865) 2290908..2292377 + 1470 WP_000287548.1 beta-Ala-His dipeptidase -
LRS65_RS11890 (LRS65_11870) 2292623..2293432 + 810 WP_000678369.1 papain-like cysteine protease family protein -
LRS65_RS11895 (LRS65_11875) 2293458..2294060 + 603 WP_000517271.1 hypothetical protein -
LRS65_RS11900 (LRS65_11880) 2294304..2294555 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28322.05 Da        Isoelectric Point: 9.0291

>T228434 WP_257116059.1 NZ_CP089601:2289061-2289798 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMKKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T228434 NZ_CP123953:1891369-1891956 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4953.36 Da        Isoelectric Point: 3.9798

>AT228434 WP_000237819.1 NZ_CP089601:2289911-2290039 [Bacillus cereus]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT228434 NZ_CP123953:1892023-1892877 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M1PKC2

References