Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1353041..1353957 | Replicon | chromosome |
| Accession | NZ_CP089592 | ||
| Organism | Bacillus subtilis strain Bsi | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | O34853 |
| Locus tag | LUV29_RS07110 | Protein ID | WP_003244695.1 |
| Coordinates | 1353211..1353957 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | LUV29_RS07105 | Protein ID | WP_003232646.1 |
| Coordinates | 1353041..1353211 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUV29_RS07070 (1349904) | 1349904..1350233 | + | 330 | WP_003232660.1 | XkdW family protein | - |
| LUV29_RS07075 (1350230) | 1350230..1350394 | + | 165 | WP_003232658.1 | XkdX family protein | - |
| LUV29_RS07080 (1350438) | 1350438..1351277 | + | 840 | WP_003245597.1 | phage-like element PBSX protein XepA | - |
| LUV29_RS07085 (1351330) | 1351330..1351599 | + | 270 | WP_003232655.1 | hemolysin XhlA family protein | - |
| LUV29_RS07090 (1351612) | 1351612..1351875 | + | 264 | WP_003232653.1 | phage holin | - |
| LUV29_RS07095 (1351888) | 1351888..1352781 | + | 894 | WP_003245230.1 | N-acetylmuramoyl-L-alanine amidase | - |
| LUV29_RS07100 (1352818) | 1352818..1352955 | - | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| LUV29_RS07105 (1353041) | 1353041..1353211 | - | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| LUV29_RS07110 (1353211) | 1353211..1353957 | - | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| LUV29_RS07115 (1354067) | 1354067..1355068 | - | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
| LUV29_RS07120 (1355081) | 1355081..1355698 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| LUV29_RS07125 (1355974) | 1355974..1357290 | - | 1317 | WP_003244819.1 | serine/threonine exchanger | - |
| LUV29_RS07130 (1357679) | 1357679..1358629 | + | 951 | WP_003245086.1 | ring-cleaving dioxygenase | - |
| LUV29_RS07135 (1358730) | 1358730..1358876 | + | 147 | WP_003244977.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1300344..1358876 | 58532 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T228390 WP_003244695.1 NZ_CP089592:c1353957-1353211 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T228390 NZ_CP123897:c5054617-5054381 [Methylomonas sp. UP202]
GTGAGCAAAAAGCAAAAGCTGATTGAGAAATTCAAATCTGATTCCGAATTCACTTGGCAGGAATTGGAAAGAATGATGCT
GCTACTGGGCTTTGAAAAACAGGAAGGCGACGGGTCGCGGGTTAAATTCTACAAACCGGAATTAACCGTCAGCATCCACA
AACCCCATCCCGACAAATCGATCAAGCACTATGTTCGAAAAGAAATTTTAGCGAGGTTAAAAGATGAATTGCTTTAG
GTGAGCAAAAAGCAAAAGCTGATTGAGAAATTCAAATCTGATTCCGAATTCACTTGGCAGGAATTGGAAAGAATGATGCT
GCTACTGGGCTTTGAAAAACAGGAAGGCGACGGGTCGCGGGTTAAATTCTACAAACCGGAATTAACCGTCAGCATCCACA
AACCCCATCCCGACAAATCGATCAAGCACTATGTTCGAAAAGAAATTTTAGCGAGGTTAAAAGATGAATTGCTTTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT228390 WP_003232646.1 NZ_CP089592:c1353211-1353041 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT228390 NZ_CP123897:c5054394-5054056 [Methylomonas sp. UP202]
ATGAATTGCTTTAGCTACAAGGGCTATCAAGGCTCGGTTGAAACCAGCATTCAGGATAAATGCCTCTACGGCAAATTGCT
TAACATTACCGATCTAATTCTCTACGAAGGCAACACCGTAGATGAACTGGAGCAAAATTTTAAAGCCTCGGTAGACGATT
ATCTGGAGCACTGCAAACAGCAAAATAAACCGCCTAAAAAGCCGTTCAAAGGCTCCTTCAATGTCAGAATCGGCCAGGAA
CTCCACGAAAAAGCCAGCAAAAGGGCCAGCGAAATCGGCAAATCCCTGAATGAGTATATAAAGGATATTGTGCAGAAAGA
CACCGAATCGCATGCCTAA
ATGAATTGCTTTAGCTACAAGGGCTATCAAGGCTCGGTTGAAACCAGCATTCAGGATAAATGCCTCTACGGCAAATTGCT
TAACATTACCGATCTAATTCTCTACGAAGGCAACACCGTAGATGAACTGGAGCAAAATTTTAAAGCCTCGGTAGACGATT
ATCTGGAGCACTGCAAACAGCAAAATAAACCGCCTAAAAAGCCGTTCAAAGGCTCCTTCAATGTCAGAATCGGCCAGGAA
CTCCACGAAAAAGCCAGCAAAAGGGCCAGCGAAATCGGCAAATCCCTGAATGAGTATATAAAGGATATTGTGCAGAAAGA
CACCGAATCGCATGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|