Detailed information of TA system TA228388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2982580..2983100
• Replicon: chromosome
• Accession: NZ_CP089590
• Organism: Microbacterium sp. J1-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LRQ07_RS14525
• Protein ID: WP_248541022.1
• Coordinates: 2982580..2982843 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LRQ07_RS14530
• Protein ID: WP_134352170.1
• Coordinates: 2982840..2983100 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRQ07_RS14500 (LRQ07_14490)	2978129..2979526	+	1398	WP_232763456.1	MFS transporter	-
LRQ07_RS14505 (LRQ07_14495)	2979523..2980380	+	858	WP_256535026.1	endo alpha-1,4 polygalactosaminidase	-
LRQ07_RS14510 (LRQ07_14500)	2980471..2981511	+	1041	WP_256535027.1	iron-containing redox enzyme family protein	-
LRQ07_RS14515 (LRQ07_14505)	2981508..2981714	+	207	WP_047523425.1	CDGSH iron-sulfur domain-containing protein	-
LRQ07_RS14520 (LRQ07_14510)	2981780..2982565	+	786	WP_256535028.1	DNA/RNA non-specific endonuclease	-
LRQ07_RS14525 (LRQ07_14515)	2982580..2982843	-	264	WP_248541022.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LRQ07_RS14530 (LRQ07_14520)	2982840..2983100	-	261	WP_134352170.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LRQ07_RS14535 (LRQ07_14525)	2983191..2984279	-	1089	WP_256535029.1	alkene reductase	-
LRQ07_RS14540 (LRQ07_14530)	2984317..2984814	-	498	WP_131492306.1	MarR family transcriptional regulator	-
LRQ07_RS14545 (LRQ07_14535)	2984868..2985023	+	156	WP_256535030.1	hypothetical protein	-
LRQ07_RS14550 (LRQ07_14540)	2985580..2986035	-	456	WP_047524442.1	MarR family transcriptional regulator	-
LRQ07_RS14555 (LRQ07_14545)	2986037..2987749	-	1713	WP_256535031.1	MDR family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-75)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10236.75 Da
• Isoelectric Point: 10.3288

>T228388 WP_248541022.1 NZ_CP089590:c2982843-2982580 [Microbacterium sp. J1-1]
VTAYRVEFTTAAAKEVRKLDPQNRRRILAGISELEREPRPHGVRKLAGYDNAWRVRVGDYRVLYEVIDDRVLVTVVRVAH
RRDVYEM

Nucleotide

• Length: 264 bp

>T228388 NZ_CP123897:c3724413-3724117 [Methylomonas sp. UP202]
ATGGAGAAACAAACACCCCATTGTAAACTGTCGGTTATCAAGGCACTAATTGCCGACGGTAAGATTAGAACGACTAAAAG
CGCACGAGAAGGCGCGGCGGCTTTGGGATTTGATTTTGATGACATGCTGGCGGTAATCCTGGAGTTAACTGGAGCGGATT
TTTACAAAAGCATGAGCACCCATGCCGACCATAAGGTTTGGCAGGATGTTTACCGGCCTAAAACTGTGGCCGGCGATGTT
TATTTGAAATTAACTGTCGTTGATGATGTGTTGGTCGTTTCGTTTAAGGAGTTGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9170.19 Da
• Isoelectric Point: 4.2797

>AT228388 WP_134352170.1 NZ_CP089590:c2983100-2982840 [Microbacterium sp. J1-1]
MNTISRSVPSKDLRDSLADVLGGVAYGSERVGVTRHGKLTAVVISVDDLELLEELEAARDAAEFAAARTADDGQRVTLDE
LRSEVA

Nucleotide

• Length: 261 bp

>AT228388 NZ_CP123897:c3724114-3723713 [Methylomonas sp. UP202]
ATGAAATGTCCGTCTTGCGGCGCTGCCGAGCTGGTGGGGGATACCCGAGACATGCCTTACATCTACAAAGGCGAGTCTAC
GATGATTCCCGACGTAACCGGCGAATTTTGCCCGGCCTGCGATGAAGTGATTACCGATGCCGACGAATCCCGGCGCACGA
TGGCTTTGATGATTGAATTCAACAAGCAGGTCAATGCGTCGATTGTTGACCCCAGCTTTATTGCCAGCGTCCGCAAAAAA
TTGGCACTCGACCAAAAGGAAGCATCGGAGATTTTCGGTGGCGGTATCAATGCCTTTTCCCGCTACGAGAACGGCAAAAC
CAAGCCACCGCTGGCGCTGGTCAAACTTCTAAAAGTCCTAGACCGACATCCGGATTTGTTGGACGAAGTTCGGACGGATT
AG