Detailed information of TA system TA228373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 160597..161373
• Replicon: chromosome
• Accession: NZ_CP089586
• Organism: Staphylococcus aureus strain E1185_IV_ST12

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: LUU82_RS01075
• Protein ID: WP_000031108.1
• Coordinates: 161221..161373 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LUU82_RS01070
• Protein ID: WP_001251226.1
• Coordinates: 160597..161196 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUU82_RS01050 (156513)	156513..157970	+	1458	WP_000649907.1	ABC transporter permease subunit	-
LUU82_RS01055 (157963)	157963..158685	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LUU82_RS01060 (158836)	158836..159963	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
LUU82_RS01065 (159968)	159968..160438	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LUU82_RS01070 (160597)	160597..161196	+	600	WP_001251226.1	glucosamine-6-phosphate isomerase	Antitoxin
LUU82_RS01075 (161221)	161221..161373	+	153	WP_000031108.1	SAS053 family protein	Toxin
LUU82_RS01080 (162150)	162150..162545	+	396	WP_000901023.1	hypothetical protein	-
LUU82_RS01085 (162741)	162741..164126	+	1386	WP_000116231.1	class II fumarate hydratase	-
LUU82_RS01090 (164579)	164579..165400	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T228373 WP_000031108.1 NZ_CP089586:161221-161373 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T228373 NZ_CP123854:2257191-2257580 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22373.50 Da
• Isoelectric Point: 5.1445

>AT228373 WP_001251226.1 NZ_CP089586:160597-161196 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAATGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT228373 NZ_CP123854:2256927-2257184 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: X5E2E6