Detailed information of TA system TA228362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 4762858..4763429
• Replicon: chromosome
• Accession: NZ_CP089536
• Organism: Streptomyces sp. HNM0561

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LUV23_RS19085
• Protein ID: WP_079257839.1
• Coordinates: 4762858..4763232 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1P8XVF0
• Locus tag: LUV23_RS19090
• Protein ID: WP_069863663.1
• Coordinates: 4763232..4763429 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUV23_RS19070 (LUV23_19070)	4758236..4759021	-	786	WP_069863678.1	S16 family serine protease	-
LUV23_RS19075 (LUV23_19075)	4759164..4759805	-	642	WP_069863676.1	helix-turn-helix domain-containing protein	-
LUV23_RS19080 (LUV23_19080)	4760950..4762746	-	1797	WP_079152962.1	DEAD/DEAH box helicase	-
LUV23_RS19085 (LUV23_19085)	4762858..4763232	-	375	WP_079257839.1	Fic family protein	Toxin
LUV23_RS19090 (LUV23_19090)	4763232..4763429	-	198	WP_069863663.1	Arc family DNA-binding protein	Antitoxin
LUV23_RS19095 (LUV23_19095)	4763463..4764956	-	1494	WP_206332558.1	MFS transporter	-
LUV23_RS19100 (LUV23_19100)	4765262..4766368	-	1107	WP_232564531.1	putative sulfate exporter family transporter	-
LUV23_RS19105 (LUV23_19105)	4766365..4766934	-	570	WP_079257842.1	cysteine dioxygenase family protein	-
LUV23_RS19110 (LUV23_19110)	4767108..4768013	-	906	WP_069863657.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-80)

Antitoxin

• Arc-like DNA binding domain (4-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14001.81 Da
• Isoelectric Point: 4.7465

>T228362 WP_079257839.1 NZ_CP089536:c4763232-4762858 [Streptomyces sp. HNM0561]
MHYLTLPELLNLAERLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESSARNHALVDGNKRLSWYATWVFL
HINGHPLHADFDVDEAERFVLSVCQGELDVAKIAEGLTRFTERM

Nucleotide

• Length: 375 bp

>T228362 NZ_CP123852:2672358-2672567 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7439.31 Da
• Isoelectric Point: 5.6033

>AT228362 WP_069863663.1 NZ_CP089536:c4763429-4763232 [Streptomyces sp. HNM0561]
MAALNLRFTDEELDALRKRAEAEGRSMQSFAHDAVMAAINEHSRRFDEAADHVLRVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT228362 NZ_CP123852:2672053-2672346 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A1P8XVF0