228360

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3359257..3359950 Replicon chromosome
Accession NZ_CP089532
Organism Pseudomonas veronii strain G2

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag LUW10_RS15115 Protein ID WP_003151133.1
Coordinates 3359257..3359634 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag LUW10_RS15120 Protein ID WP_001172026.1
Coordinates 3359615..3359950 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW10_RS15105 (LUW10_15105) 3355450..3358479 - 3030 WP_010799689.1 Tn3 family transposase -
LUW10_RS15110 (LUW10_15110) 3358463..3359065 - 603 WP_010465829.1 recombinase family protein -
LUW10_RS15115 (LUW10_15115) 3359257..3359634 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUW10_RS15120 (LUW10_15120) 3359615..3359950 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
LUW10_RS15125 (LUW10_15125) 3359965..3360300 + 336 WP_000741275.1 hypothetical protein -
LUW10_RS15130 (LUW10_15130) 3360324..3360650 + 327 WP_000091614.1 hypothetical protein -
LUW10_RS15135 (LUW10_15135) 3360647..3361018 + 372 WP_023294894.1 hypothetical protein -
LUW10_RS15140 (LUW10_15140) 3361183..3361914 - 732 WP_017846225.1 GntR family transcriptional regulator -
LUW10_RS15145 (LUW10_15145) 3362120..3362626 - 507 WP_232591839.1 AAA family ATPase -
LUW10_RS15150 (LUW10_15150) 3362940..3364256 + 1317 WP_017846227.1 flagellar hook protein FlgE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T228360 WP_003151133.1 NZ_CP089532:3359257-3359634 [Pseudomonas veronii]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T228360 NZ_CP123852:2335879-2335986 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT228360 WP_001172026.1 NZ_CP089532:3359615-3359950 [Pseudomonas veronii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT228360 NZ_CP123852:c2336063-2336003 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACTAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References