Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2025675..2026279 Replicon chromosome
Accession NZ_CP089519
Organism Pseudomonas extremorientalis strain 1502IPR-01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LUU92_RS09175 Protein ID WP_222541321.1
Coordinates 2025675..2025863 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LUU92_RS09180 Protein ID WP_257103492.1
Coordinates 2025875..2026279 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUU92_RS09145 (LUU92_09135) 2021032..2021568 + 537 WP_071488488.1 DsbE family thiol:disulfide interchange protein -
LUU92_RS09150 (LUU92_09140) 2021565..2022038 + 474 WP_071488487.1 cytochrome c-type biogenesis protein CcmH -
LUU92_RS09155 (LUU92_09145) 2022031..2023215 + 1185 WP_071488486.1 c-type cytochrome biogenesis protein CcmI -
LUU92_RS09160 (LUU92_09150) 2023231..2023623 + 393 WP_071488485.1 hypothetical protein -
LUU92_RS09165 (LUU92_09155) 2024004..2024576 + 573 WP_257103491.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
LUU92_RS09170 (LUU92_09160) 2024606..2025484 - 879 WP_071488483.1 LysR family transcriptional regulator -
LUU92_RS09175 (LUU92_09165) 2025675..2025863 + 189 WP_222541321.1 type II toxin-antitoxin system HicA family toxin Toxin
LUU92_RS09180 (LUU92_09170) 2025875..2026279 + 405 WP_257103492.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LUU92_RS09185 (LUU92_09175) 2026654..2028183 + 1530 WP_257103493.1 M57 family metalloprotease -
LUU92_RS09190 (LUU92_09180) 2028415..2030124 + 1710 WP_257103494.1 M10 family metallopeptidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7207.45 Da        Isoelectric Point: 10.8676

>T228352 WP_222541321.1 NZ_CP089519:2025675-2025863 [Pseudomonas extremorientalis]
VQSRLLIKELQDAGWVLDRVTGSHHIFIHRYSLYTIPVPHPKKDLPLGTLRSIRKRAGLFDF

Download         Length: 189 bp

>T228352 NZ_CP123849:c219736-219353 [Agrobacterium fabacearum]
GTGATCCTGGTAGACACCTCGATCTGGATAGATCATTTTCGATACGATGACTCAGAACTACGAAAAATCATCAATGATGA
CCAGCTGCTCTGCCACCCTTTCGTTGTAGGCGAATTGGCGCTCGGCAGCTTAAGAGAGCGGGCTGCAGTTTTAGAGTTCC
TAACAGCTCAACGCGAGGCGCTAATCGCGACCCATGCAGAAGTAATGACGATCATTGATCGTCATTCGATATTCAGCATG
GGGATTGGTTACACAGATGCGCATTTACTTACTTCAACGTTGCTCGACCGGCGATCAAGCTTGTGGACAAGAGATAAGCG
CCTAGCGGCCGCAGCACAAAAAGTTGGTGCGGCACTTTACCCGCACGCGCAAGCCTCTCATTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14833.82 Da        Isoelectric Point: 4.6017

>AT228352 WP_257103492.1 NZ_CP089519:2025875-2026279 [Pseudomonas extremorientalis]
MQYPIYIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGTIPMPTSVARYHAHEDYAGMGWGM
LELDVTPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT228352 NZ_CP123849:c219933-219733 [Agrobacterium fabacearum]
ATGCGATCAACCATAAATATCGACGACAATCTTATGGAACGGGCCAAGTCCCTCACGGGCACCAAGGAAACAGCAGCTCT
CGTGCGGCAAGCGCTGGAGACACTCGTGCGTGTGGAATCCGGCAAACGGCTGATCGCGCTTGGCGGCTCTATGCCTGAGG
CTGAAGCGTCGCCGCGCCGACGGAGCGACGTGGCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References