Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1668370..1668985 Replicon chromosome
Accession NZ_CP089519
Organism Pseudomonas extremorientalis strain 1502IPR-01

Toxin (Protein)


Gene name hicA Uniprot ID I4KFU3
Locus tag LUU92_RS07360 Protein ID WP_003189411.1
Coordinates 1668803..1668985 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1H0VRD6
Locus tag LUU92_RS07355 Protein ID WP_071488915.1
Coordinates 1668370..1668780 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUU92_RS07330 (LUU92_07320) 1664192..1665133 + 942 WP_071488910.1 hydroxymethylglutaryl-CoA lyase -
LUU92_RS07335 (LUU92_07325) 1665193..1666524 + 1332 WP_257103360.1 MFS transporter -
LUU92_RS07340 (LUU92_07330) 1666689..1667216 + 528 WP_071488912.1 DUF4142 domain-containing protein -
LUU92_RS07345 (LUU92_07335) 1667272..1667697 - 426 WP_092241350.1 low affinity iron permease family protein -
LUU92_RS07350 (LUU92_07340) 1667779..1668279 - 501 WP_092241352.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
LUU92_RS07355 (LUU92_07345) 1668370..1668780 - 411 WP_071488915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LUU92_RS07360 (LUU92_07350) 1668803..1668985 - 183 WP_003189411.1 type II toxin-antitoxin system HicA family toxin Toxin
LUU92_RS07365 (LUU92_07355) 1669154..1670047 - 894 WP_093119191.1 LysR family transcriptional regulator -
LUU92_RS07370 (LUU92_07360) 1670143..1671306 + 1164 WP_257103361.1 MFS transporter -
LUU92_RS07375 (LUU92_07365) 1671303..1672472 + 1170 WP_257103362.1 MFS transporter -
LUU92_RS07380 (LUU92_07370) 1672461..1672583 - 123 Protein_1451 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6804.01 Da        Isoelectric Point: 10.7532

>T228351 WP_003189411.1 NZ_CP089519:c1668985-1668803 [Pseudomonas extremorientalis]
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T228351 NZ_CP123849:212509-213366 [Agrobacterium fabacearum]
ATGGCGAAGTCGGTCAAGGATCGGCTGCTCAATATCGCCCGCAAAGAAAGTCGCGCCTTCGACGTCTTGCTGGTGCGGTT
CGCGCTCGAACGGCTGCTGTATCGCCTGTCAATCTCAGCGCATAGGGACCGCTTCGTCCTGAAAGGCGGTATGTTGGTCA
CGGTCTGGGTGGCCGACGACAATCGGGTGACGCGGGATGCGGACTTTCTCGGACATGGGGACGCAGATCCTGCCTGCCTG
ATCGCCAACTTCGGGGAGATCATGGCGATTGAGAGCGACGACGGGCTCGTCTTCGACATCAATGCGCTCGCTGCAACAGT
CATTCGAGAAGAAATGGAATATGGCGGCGTTCGTCTCAAGACTGCAGCCTATCTCGAAAGAACCCGCATCCCCATTACAA
TCGACATCGGCTTCGGAGACGCTATGGCCGATGCGACGCAGCGGCTCGACTATCCAGCCCTGCTAGATTTTCCCGCGCCG
CAGGTTCGTTCCTATCCGCCTGCAACGGTGATCGCCGAGAAATTCCAGGCGATGGTGGCGCTTGGTGTTCTCAACGGGCG
CATGAAAGACTATTACGACCTGTGGGCGATACCGCGCGCGATCGACATTCCCGCCGACGATCTGGATGCGGCCATCCGCG
CGACGTTCGAACGCCGTAGGACGCCAATTCCTAAAGAACGCCCACCGGGCCTCTCGGTCGAGATGTTTGGCGACGAAGGG
AAGCAGCGGCAATGGCGTGCTTACGCCGCATCGCTCGAACTAGACGCTGTTTCGCTGGAATCGATCATTGAACGGGTTTG
GGAGTTGGTCGGCCAGTCATGCGCGCGGATCGTAGCAAGAAACGAGAATGAGGCATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14773.63 Da        Isoelectric Point: 4.3883

>AT228351 WP_071488915.1 NZ_CP089519:c1668780-1668370 [Pseudomonas extremorientalis]
MLYPIAISTGDDDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPSAQKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQDH

Download         Length: 411 bp

>AT228351 NZ_CP123849:211884-212495 [Agrobacterium fabacearum]
ATGCCATCGTCGCAAAAAGCAAAGCTCAGAAGCCTGCTCGCTGCGCGCAGCATGATGCGTGCGCATGAACTACGCGAGGC
TGGCATCAGCGCACAAACGATCGCGCGCGCCGTCGAGGGCGGTGAAATCGAGCGTATCTCGCGCGGCGTTTATCAGAAGC
GTGACGCGGAAGTCGAAGAGAACCAGATCCTTGCTGAAGCCATCATGCGTGCGCCCAAAGGCGTGATCGCTCTGGTGTCG
GCGCTCGCCTTCCACGGACTGACCGACCAGATGCCGCGGCGCGTCTGGATGGCGATCGGGACGAGCGATTGGGCGCCCGT
GCAGTCCTATCCCCCGCTGCGTATAGTCCGCTTCACGGAACCCTATCTGCGACAGGGCATCGAAAATCAAGTAATCGCCG
GCATTGACGTTCCGGTCTATTCGATCCCGAAAACCCTTGCTGACCTGTTCCGAAACCCCAAACTGGTGGACCGATCGGTT
GCTGTCGAAGGACTGCGTGCTGCTCTCCAGCAACGCAAGTCAACTCCAAGCGCAATCGCCCAGGCCGCGAAGGCCGGCGG
CGCCTGGAAGGTCATGCAACCCTATCTTGAGGCGCTCACCTCCAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7DFI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0VRD6

References