Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4854296..4855977 Replicon chromosome
Accession NZ_CP089509
Organism Klebsiella pneumoniae strain GD21SC417

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag LT986_RS23875 Protein ID WP_002885155.1
Coordinates 4854296..4855213 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag LT986_RS23880 Protein ID WP_004192584.1
Coordinates 4855219..4855977 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT986_RS23855 (4849602) 4849602..4851122 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
LT986_RS23860 (4851119) 4851119..4852117 + 999 WP_002885172.1 ribose ABC transporter permease -
LT986_RS23865 (4852148) 4852148..4853089 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LT986_RS23870 (4853164) 4853164..4854171 + 1008 WP_004177805.1 carbohydrate kinase family protein -
LT986_RS23875 (4854296) 4854296..4855213 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LT986_RS23880 (4855219) 4855219..4855977 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LT986_RS23885 (4856063) 4856063..4856791 - 729 WP_002885152.1 response regulator transcription factor -
LT986_RS23890 (4857064) 4857064..4859211 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
LT986_RS23895 (4859441) 4859441..4860127 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T228343 WP_002885155.1 NZ_CP089509:c4855213-4854296 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T228343 NZ_CP123840:454821-455318 [Agrobacterium fabacearum]
GTGACTCTCAGCGCACCAGTCCCCCTGGCCGATCATCACGAACTGGCCGAATTCAATTCTGGAGTACCTGAACTGGACGA
CTGGCTTCGGCGCCGTGCCCGGGCCAATCAAGCAGGCGGCGCGTCGCGGACCTTTGTCGTGTGCGACGAGAGCCGCGTCA
TCGCGTACTACGCCCTGGTCTCTGGCTTCGTGAAACCGCCGGAAGTGCCTGGTCGCTTTCGGCGCAATATGCCTGATCCA
ATCCCAGTTGCAGTGCTTGGCCGCCTCGCCATTGATCAATCCTGTCAAGGGCGTGGTATCGGCAGGGCATTGGTGCGCGA
CGCGGGTTTGCGCCTGCTGAATGCCGCTGAAGTGCTCGGGATCCGCGGCGTGCTGGTCCATGCGATTTCTGATGACGCAC
GAGCCTTCTACGAAGCCGTCGGCTTCCTGTCTTCTCCGTCCGATCCCATGATGCTGATGGTCGGTTTGCACGACCTCAAT
AACGCGCTGAATACCTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT228343 WP_004192584.1 NZ_CP089509:c4855977-4855219 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT228343 NZ_CP123840:454528-454824 [Agrobacterium fabacearum]
ATGCCGACCTCACACACGGGTAAGAGCCCGGACGCAAGTGTGCAGCTGAATATGCGCATCAAACCTGCTACTCGCAACTT
GATCGATCGCGCCGCGGAGTTGCTCGGCAAAACGCGCACAGATTTCATGTTGGAAGCTTCCGAGCGCCGTGCGGAGGAGG
TGCTGCTCGACCGTACAATCGTCACGGTAAGCCCCGAAATTTATGCCGAATATCTTGCCCGTCTCGATGCGCCTGCACAG
CCCAATGAGCGTCTAAAGCGCACGATGTCGACCAAAGCGCCCTGGGATGAGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References