Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4690275..4690791 Replicon chromosome
Accession NZ_CP089509
Organism Klebsiella pneumoniae strain GD21SC417

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag LT986_RS23050 Protein ID WP_004192395.1
Coordinates 4690275..4690559 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag LT986_RS23055 Protein ID WP_004192397.1
Coordinates 4690549..4690791 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT986_RS23025 (4685692) 4685692..4685955 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LT986_RS23030 (4686085) 4686085..4686258 + 174 WP_002886906.1 hypothetical protein -
LT986_RS23035 (4686261) 4686261..4687004 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LT986_RS23040 (4687361) 4687361..4689499 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LT986_RS23045 (4689807) 4689807..4690271 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LT986_RS23050 (4690275) 4690275..4690559 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT986_RS23055 (4690549) 4690549..4690791 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LT986_RS23060 (4690869) 4690869..4692779 - 1911 WP_004152270.1 PRD domain-containing protein -
LT986_RS23065 (4692802) 4692802..4693956 - 1155 WP_004178372.1 lactonase family protein -
LT986_RS23070 (4694023) 4694023..4694763 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T228342 WP_004192395.1 NZ_CP089509:c4690559-4690275 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T228342 NZ_CP123840:442283-442702 [Agrobacterium fabacearum]
ATGATCTTGCTTGACACCAACGTCATATCCGAACCTTGGAAACCGGTTCCGGACGAGGCGGTGATTGCCTGGTTGGACGC
CCAAGCTGTCGAAACGCTGTTCATCTCCGCAATAACGATTGCGGAACTTCGCTTCGGAATTGCTGCTATGCCTTCAGGCA
GACGGCAAACTATCCTCCGCGACCGTCTCGAGGGGGAGGTGCTGCCACACTTTTCCGGCCGCATCCTGTCCTTCGATCTG
ACTACTTCTCAGTTCTACTCTGAACTGATGGCACGCGCTCGAGCGTCTGGGAAAGCAATCGGCACGGCCGATGGCTACAT
TGCAGCCACAGCGGCAGCAAATGGCCTCACTATCTCAACTCGCGATACAAGCCCTTTCGAGGCTGCCGGGGTGAAAGTGA
TCAACCCCTGGTCCAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT228342 WP_004192397.1 NZ_CP089509:c4690791-4690549 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT228342 NZ_CP123840:442032-442286 [Agrobacterium fabacearum]
ATGCCGGCAGTCACCATTCGTAACCTTTCTGAAGAAACACATCGCGCTCTGAGGGTGCGAGCGGCTCATCATGGCCGGAG
CACGGAGGCCGAGATTCGTGCCATTATTGAAGCGGCTGTTCGTCCTCCGGAACGTATTCAGCTCGGTTCCTTGCTAGCGG
CCATTGGTCGCGACGCCGAGCTTTCCAACAGCGACGTTGAAGCTCTTCAGAAAAGTCGCGACAAGACACCTGCTAAGCCG
ATGACCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References