Detailed information of TA system TA022834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2120888..2121536
• Replicon: chromosome
• Accession: NC_010622
• Organism: Burkholderia phymatum STM815

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BPHY_RS09445
• Protein ID: WP_041763899.1
• Coordinates: 2120888..2121064 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2JCY0
• Locus tag: BPHY_RS09450
• Protein ID: WP_012401246.1
• Coordinates: 2121120..2121536 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPHY_RS09405	2116955..2117227	+	273	WP_012401240.1	hypothetical protein	-
BPHY_RS09410	2117245..2117616	-	372	WP_012401241.1	DUF2591 domain-containing protein	-
BPHY_RS09415	2117905..2118543	+	639	WP_157686570.1	SGNH/GDSL hydrolase family protein	-
BPHY_RS09420	2118567..2118869	-	303	WP_052306104.1	PAAR domain-containing protein	-
BPHY_RS09425	2119125..2119346	+	222	WP_041763502.1	hypothetical protein	-
BPHY_RS09435	2119993..2120178	+	186	WP_041763504.1	hypothetical protein	-
BPHY_RS09440	2120192..2120809	+	618	WP_012401244.1	DNA ligase	-
BPHY_RS09445	2120888..2121064	+	177	WP_041763899.1	type II toxin-antitoxin system HicA family toxin	Toxin
BPHY_RS09450	2121120..2121536	+	417	WP_012401246.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BPHY_RS09455	2121569..2121874	+	306	WP_041763505.1	hypothetical protein	-
BPHY_RS09460	2121909..2122289	-	381	WP_012401247.1	DUF1353 domain-containing protein	-
BPHY_RS09465	2122289..2122708	-	420	WP_012401248.1	hypothetical protein	-
BPHY_RS09470	2122750..2122962	-	213	WP_012401249.1	hypothetical protein	-
BPHY_RS41665	2123014..2123853	-	840	WP_012401250.1	hypothetical protein	-
BPHY_RS09485	2123922..2124419	-	498	WP_012401251.1	hypothetical protein	-
BPHY_RS09490	2124416..2124988	-	573	WP_012401252.1	lysozyme	-
BPHY_RS09495	2124990..2125289	-	300	WP_041763509.1	hypothetical protein	-
BPHY_RS09500	2125474..2125758	+	285	WP_012401254.1	hypothetical protein	-
BPHY_RS09505	2125761..2126453	+	693	WP_012401255.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2120171..2181561	61390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (92-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6653.66 Da
• Isoelectric Point: 11.0174

>T22834 WP_041763899.1 NC_010622:2120888-2121064 [Paraburkholderia phymatum STM815]
VKQSEFKRWLADQGARFKEGSNHTKVYLNGKQTTLPRHPGHEIGEGLRQKILKQLGLK

Nucleotide

• Length: 177 bp

>T22834 NC_010622:2120888-2121064 [Paraburkholderia phymatum STM815]
GTGAAACAGAGTGAGTTCAAGAGGTGGTTAGCTGATCAGGGCGCGAGATTCAAGGAAGGATCGAATCACACGAAGGTCTA
CCTGAACGGCAAACAAACCACCCTGCCGAGGCACCCCGGCCACGAAATCGGGGAAGGTCTGAGGCAGAAGATTCTGAAGC
AGCTCGGTCTGAAGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15062.33 Da
• Isoelectric Point: 4.6928

>AT22834 WP_012401246.1 NC_010622:2121120-2121536 [Paraburkholderia phymatum STM815]
MLRYPALFEPDGDGFAVSFRDIPEALTSGETMEEARAMAADALLTAMDFYFEDRRPVPEPSKAKKGEELVALPASVSAKV
LLLNEMIRQQVTPSELARRLGTSPQVVNRIVDVKHATKIDTIAEALEALGKHLEIGVA

Nucleotide

• Length: 417 bp

>AT22834 NC_010622:2121120-2121536 [Paraburkholderia phymatum STM815]
ATGTTGCGTTACCCCGCCCTGTTCGAACCGGATGGCGACGGATTCGCCGTGTCATTTCGGGACATCCCCGAAGCGCTGAC
CAGTGGCGAGACGATGGAAGAAGCTCGAGCGATGGCGGCAGACGCGCTGCTGACGGCGATGGACTTCTATTTCGAAGATC
GCCGCCCGGTGCCCGAGCCGTCGAAGGCCAAAAAGGGCGAGGAACTCGTCGCCCTGCCCGCCAGCGTATCGGCCAAGGTA
TTACTGCTGAACGAGATGATCCGCCAGCAGGTGACGCCATCCGAGCTCGCGCGTCGCCTCGGAACTAGTCCACAGGTCGT
GAATCGGATCGTCGACGTCAAGCACGCGACGAAGATTGATACTATTGCCGAGGCCCTCGAGGCCCTAGGCAAACATCTCG
AAATTGGAGTCGCTTGA

Structures

Antitoxin

• AlphaFold DB: B2JCY0