Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2609052..2610640 Replicon chromosome
Accession NZ_CP089509
Organism Klebsiella pneumoniae strain GD21SC417

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag LT986_RS12910 Protein ID WP_004190166.1
Coordinates 2609052..2610374 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LT986_RS12915 Protein ID WP_002904790.1
Coordinates 2610374..2610640 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT986_RS12895 (2604108) 2604108..2606609 + 2502 WP_102010286.1 fimbria/pilus outer membrane usher protein -
LT986_RS12900 (2606597) 2606597..2607601 + 1005 WP_004190163.1 fimbrial protein -
LT986_RS12905 (2607743) 2607743..2609035 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LT986_RS12910 (2609052) 2609052..2610374 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
LT986_RS12915 (2610374) 2610374..2610640 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LT986_RS12920 (2610905) 2610905..2611231 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LT986_RS12925 (2611228) 2611228..2611728 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LT986_RS12930 (2611706) 2611706..2613085 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LT986_RS12935 (2613431) 2613431..2614585 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LT986_RS12940 (2614566) 2614566..2615489 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2408481..2651183 242702


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T228338 WP_004190166.1 NZ_CP089509:c2610374-2609052 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T228338 NZ_CP123782:c406094-405795 [Minwuia sp. IMCC3060]
ATGCCGGATAGCGATCCGGGCTACCGGCTTTCTCCGCTCGCGAGAACCGATCTGGAAGACATCTGGCGCTACACCTTCGA
GAACTGGTCGCTTGAACAGGCGGATCGCTACCATGGCACGATCATGACCGCGATCCTGGCGTTGGCTGATGGCTCAGTAT
CGGGTAGCCGCGCCGACGTCCGTGAGGGCTATTTCAAGCTAAGAGCCGGTTCCCATGTCCTGTTCTACCGAAAGGCCGAC
ACCACTCTGGAGATCATGCGCATCCTGCATCAGCGCATGGACGTGGATCGACACCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT228338 WP_002904790.1 NZ_CP089509:c2610640-2610374 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT228338 NZ_CP123782:c406329-406084 [Minwuia sp. IMCC3060]
ATGGCACGCAATACCTCGGTCTCGCTTGGTGATCATTTCACCGGCTTCATTGACAGTCAGGTTCGGGACGGTCGCTACGG
CTCCGCCAGCGATGTGGTCAGGGCTGGTCTGCGGCTGCTGGAGGAACATGAAACCAGGGTCCGAGCCTTGCAGAACGCCC
TGATCGCCGCAGAGGAATCCGGTCCCCCAGAAGCTTTCGACAGCGATGCCTTCCTGGAGGAAATGCGGAAGAAGCATGCC
GGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References