Detailed information of TA system TA022833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 5659093..5659732
• Replicon: chromosome
• Accession: NC_010612
• Organism: Mycobacterium marinum M

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MMAR_RS23140
• Protein ID: WP_012396162.1
• Coordinates: 5659093..5659539 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: B2HEJ8
• Locus tag: MMAR_RS23145
• Protein ID: WP_011738542.1
• Coordinates: 5659544..5659732 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMAR_RS23115	5654268..5655788	+	1521	WP_012396157.1	carotenoid oxygenase family protein	-
MMAR_RS23120	5655805..5656278	+	474	WP_012396158.1	VOC family protein	-
MMAR_RS23125	5656284..5656718	-	435	WP_012396159.1	hypothetical protein	-
MMAR_RS23130	5656789..5657562	-	774	WP_012396160.1	VOC family protein	-
MMAR_RS23135	5657728..5658981	+	1254	WP_012396161.1	hypothetical protein	-
MMAR_RS23140	5659093..5659539	-	447	WP_012396162.1	SRPBCC family protein	Toxin
MMAR_RS23145	5659544..5659732	-	189	WP_011738542.1	antitoxin	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 15851.39 Da
• Isoelectric Point: 8.6574

>T22833 WP_012396162.1 NC_010612:c5659539-5659093 [Mycobacterium marinum M]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPSAAG

Nucleotide

• Length: 447 bp

>T22833 NC_010612:c5659539-5659093 [Mycobacterium marinum M]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGATCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCAGCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGTCGGCTGCCGGCTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6586.35 Da
• Isoelectric Point: 4.7205

>AT22833 WP_011738542.1 NC_010612:c5659732-5659544 [Mycobacterium marinum M]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Nucleotide

• Length: 189 bp

>AT22833 NC_010612:c5659732-5659544 [Mycobacterium marinum M]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAGGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7LB02