Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812928..813585 Replicon chromosome
Accession NZ_CP089509
Organism Klebsiella pneumoniae strain GD21SC417

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LT986_RS04040 Protein ID WP_002916310.1
Coordinates 813175..813585 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LT986_RS04035 Protein ID WP_002916312.1
Coordinates 812928..813194 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT986_RS04010 (808084) 808084..809517 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LT986_RS04015 (809636) 809636..810364 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LT986_RS04020 (810414) 810414..810725 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LT986_RS04025 (810889) 810889..811548 + 660 WP_002916317.1 hemolysin III family protein -
LT986_RS04030 (811699) 811699..812682 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LT986_RS04035 (812928) 812928..813194 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LT986_RS04040 (813175) 813175..813585 + 411 WP_002916310.1 protein YgfX Toxin
LT986_RS04045 (813592) 813592..814113 - 522 WP_002916308.1 flavodoxin FldB -
LT986_RS04050 (814214) 814214..815110 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LT986_RS04055 (815133) 815133..815846 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LT986_RS04060 (815852) 815852..817585 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T228329 WP_002916310.1 NZ_CP089509:813175-813585 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228329 NZ_CP123768:c1392-1072 [Acinetobacter pittii]
ATGCTATTCATTGAAACTAGTATTTTCACCAAGCAAATCAAAGAGCTTGTCTCTGATGATGAATACAGAGAACTCCAACA
GGAACTTTTAGTTCAGCCAGATAAAGGAGATCTCATAAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAAGGTA
GTAAAGGAAAAAGTGGTGGCATCCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATCTTTATGCTACTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCACTATCCTACGTCAACTTGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228329 WP_002916312.1 NZ_CP089509:812928-813194 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228329 NZ_CP123768:c1079-807 [Acinetobacter pittii]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCGATTAAACGTAATGAAGTTCAAGCAAG
TCGAGTGACTGAGTTGACTCTTCCTGATATTAAAGAAGTTCGAGAAAAAACAGGTTTGAGCCAAACCGAATTTGCTGCAC
GTTTACATATTAGCCCTCGTACACTTCAGAATTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCTTGATT
CGTATTCTAGATGCGCATCCAAGCCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References