Detailed information of TA system TA022832

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3463111..3463764
• Replicon: chromosome
• Accession: NC_010611
• Organism: Acinetobacter baumannii ACICU

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ACICU_RS16265
• Protein ID: WP_000607077.1
• Coordinates: 3463111..3463500 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: ACICU_RS16270
• Protein ID: WP_001288210.1
• Coordinates: 3463507..3463764 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACICU_RS16250	3458229..3460424	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
ACICU_RS16255	3460612..3461178	-	567	WP_000651538.1	rhombosortase	-
ACICU_RS16260	3461256..3462341	-	1086	WP_000049106.1	hypothetical protein	-
ACICU_RS16265	3463111..3463500	-	390	WP_000607077.1	membrane protein	Toxin
ACICU_RS16270	3463507..3463764	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
ACICU_RS16275	3463952..3465124	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
ACICU_RS16280	3465173..3466663	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
ACICU_RS16285	3466845..3467222	-	378	WP_001216380.1	50S ribosomal protein L17	-
ACICU_RS16290	3467241..3468248	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T22832 WP_000607077.1 NC_010611:c3463500-3463111 [Acinetobacter baumannii ACICU]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T22832 NC_010611:c3463500-3463111 [Acinetobacter baumannii ACICU]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT22832 WP_001288210.1 NC_010611:c3463764-3463507 [Acinetobacter baumannii ACICU]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT22832 NC_010611:c3463764-3463507 [Acinetobacter baumannii ACICU]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7