Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2903434..2904085 Replicon chromosome
Accession NC_010611
Organism Acinetobacter baumannii ACICU

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag ACICU_RS13610 Protein ID WP_000838146.1
Coordinates 2903903..2904085 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag ACICU_RS13605 Protein ID WP_000966689.1
Coordinates 2903434..2903838 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACICU_RS13590 2898467..2898808 - 342 WP_001281459.1 phage tail protein -
ACICU_RS13595 2898926..2902891 - 3966 WP_000191304.1 tape measure protein -
ACICU_RS13600 2902952..2903353 - 402 WP_000720591.1 hypothetical protein -
ACICU_RS13605 2903434..2903838 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ACICU_RS13610 2903903..2904085 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
ACICU_RS13615 2904417..2904950 - 534 WP_001185622.1 hypothetical protein -
ACICU_RS13620 2904995..2905924 - 930 WP_000094299.1 hypothetical protein -
ACICU_RS13625 2906032..2906244 - 213 WP_000121166.1 hypothetical protein -
ACICU_RS13630 2906246..2906644 - 399 WP_001132270.1 hypothetical protein -
ACICU_RS13635 2906646..2907014 - 369 WP_000539752.1 hypothetical protein -
ACICU_RS13640 2906986..2907390 - 405 WP_000248323.1 hypothetical protein -
ACICU_RS13645 2907399..2907767 - 369 WP_000524231.1 hypothetical protein -
ACICU_RS13650 2907769..2908158 - 390 WP_000008492.1 hypothetical protein -
ACICU_RS13655 2908163..2908828 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2878776..2938460 59684


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T22831 WP_000838146.1 NC_010611:c2904085-2903903 [Acinetobacter baumannii ACICU]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T22831 NC_010611:c2904085-2903903 [Acinetobacter baumannii ACICU]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT22831 WP_000966689.1 NC_010611:c2903838-2903434 [Acinetobacter baumannii ACICU]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT22831 NC_010611:c2903838-2903434 [Acinetobacter baumannii ACICU]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References