Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4056411..4057245 | Replicon | chromosome |
| Accession | NZ_CP089445 | ||
| Organism | Escherichia coli strain 5-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | LT922_RS19885 | Protein ID | WP_000854690.1 |
| Coordinates | 4056868..4057245 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | LT922_RS19880 | Protein ID | WP_001305076.1 |
| Coordinates | 4056411..4056779 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LT922_RS19840 (4051493) | 4051493..4052620 | + | 1128 | Protein_3883 | hypothetical protein | - |
| LT922_RS19845 (4052696) | 4052696..4053151 | + | 456 | WP_000581502.1 | IrmA family protein | - |
| LT922_RS19850 (4053230) | 4053230..4053463 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| LT922_RS19855 (4053564) | 4053564..4054382 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| LT922_RS19860 (4054437) | 4054437..4054922 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| LT922_RS19865 (4054938) | 4054938..4055414 | + | 477 | WP_001186726.1 | RadC family protein | - |
| LT922_RS19870 (4055477) | 4055477..4055698 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| LT922_RS19875 (4055717) | 4055717..4056361 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| LT922_RS19880 (4056411) | 4056411..4056779 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LT922_RS19885 (4056868) | 4056868..4057245 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| LT922_RS19890 (4057242) | 4057242..4057730 | + | 489 | WP_000761699.1 | DUF5983 family protein | - |
| LT922_RS19895 (4057747) | 4057747..4057944 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| LT922_RS19900 (4058029) | 4058029..4058874 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| LT922_RS19905 (4058943) | 4058943..4059338 | + | 396 | WP_000208382.1 | DUF6088 family protein | - |
| LT922_RS19910 (4059331) | 4059331..4060264 | + | 934 | Protein_3897 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LT922_RS19915 (4060681) | 4060681..4060851 | + | 171 | Protein_3898 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT | 4012133..4074822 | 62689 | |
| - | flank | IS/Tn | - | - | 4060696..4060851 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T228299 WP_000854690.1 NZ_CP089445:4056868-4057245 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T228299 NZ_CP123660:c1166891-1166562 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGACGAAGCCCTGTCTGTCGCCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGTTGGATCAACACTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATAAAACAGTTATTCAGGAATATATTA
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGACCGAAAGGGATTT
TCATGGCAAGAACAGAGCCCGTATCTTTCCGTAGTGGATATTTTGCAAGCAAGACGCTCTACTGGCTTGCTAAAAACTGA
CGTGAAATAA
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGACGAAGCCCTGTCTGTCGCCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGTTGGATCAACACTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATAAAACAGTTATTCAGGAATATATTA
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGACCGAAAGGGATTT
TCATGGCAAGAACAGAGCCCGTATCTTTCCGTAGTGGATATTTTGCAAGCAAGACGCTCTACTGGCTTGCTAAAAACTGA
CGTGAAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT228299 WP_001305076.1 NZ_CP089445:4056411-4056779 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT228299 NZ_CP123660:c1167229-1166912 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATTTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCCGAATGCCGGAGGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGCGTCATCCTGTATCAC
AACGGTTTCACCTGCGAAGCCGACACTCTTGGCAGTTGCGGCTATGTATACATCGCCGTCTATCCCACTCAACGCTAA
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATTTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCCGAATGCCGGAGGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGCGTCATCCTGTATCAC
AACGGTTTCACCTGCGAAGCCGACACTCTTGGCAGTTGCGGCTATGTATACATCGCCGTCTATCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|