Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 803027..803547 Replicon chromosome
Accession NZ_CP089445
Organism Escherichia coli strain 5-1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag LT922_RS03875 Protein ID WP_001160964.1
Coordinates 803263..803547 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag LT922_RS03870 Protein ID WP_000125566.1
Coordinates 803027..803260 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT922_RS03845 (798100) 798100..798387 + 288 WP_000203744.1 ferredoxin-like protein FixX -
LT922_RS03850 (798446) 798446..799777 + 1332 WP_001183209.1 MFS transporter -
LT922_RS03855 (799885) 799885..800415 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
LT922_RS03860 (800408) 800408..802270 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
LT922_RS03865 (802462) 802462..802941 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
LT922_RS03870 (803027) 803027..803260 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LT922_RS03875 (803263) 803263..803547 + 285 WP_001160964.1 CcdB family protein Toxin
LT922_RS03880 (803574) 803574..804422 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
LT922_RS03885 (804429) 804429..804806 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
LT922_RS03890 (804809) 804809..805630 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LT922_RS03895 (805627) 805627..806616 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
LT922_RS03900 (806616) 806616..807902 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T228278 WP_001160964.1 NZ_CP089445:803263-803547 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

>T228278 NZ_CP123607:3782963-3783166 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCAGATCATCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT228278 WP_000125566.1 NZ_CP089445:803027-803260 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT228278 NZ_CP123607:3782545-3782913 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References