Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3875097..3875716 Replicon chromosome
Accession NZ_CP089441
Organism Klebsiella quasipneumoniae strain GLW9C22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LT990_RS18895 Protein ID WP_002892050.1
Coordinates 3875498..3875716 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LT990_RS18890 Protein ID WP_002892066.1
Coordinates 3875097..3875471 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT990_RS18880 (3870251) 3870251..3871444 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LT990_RS18885 (3871467) 3871467..3874613 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
LT990_RS18890 (3875097) 3875097..3875471 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LT990_RS18895 (3875498) 3875498..3875716 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LT990_RS18900 (3875875) 3875875..3876441 + 567 WP_023288643.1 maltose O-acetyltransferase -
LT990_RS18905 (3876413) 3876413..3876544 - 132 WP_162543094.1 hypothetical protein -
LT990_RS18910 (3876578) 3876578..3877048 + 471 WP_064155186.1 YlaC family protein -
LT990_RS18915 (3877017) 3877017..3878474 - 1458 WP_087827730.1 PLP-dependent aminotransferase family protein -
LT990_RS18920 (3878575) 3878575..3879273 + 699 WP_044521289.1 GNAT family protein -
LT990_RS18925 (3879270) 3879270..3879410 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LT990_RS18930 (3879410) 3879410..3879673 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T228267 WP_002892050.1 NZ_CP089441:3875498-3875716 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T228267 NZ_CP123598:c2389558-2389340 [Enterobacter cloacae]
ATGTCTGATAAACCACTCACAAAAACCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACTCTCGAACGCGT
GATTGAAAAAAATAAATACGAGCTTTCTGATAATGAACTGACCGTATTTTATTCAGCCGCTGACCATCGTCTTGCCGAGC
TGACCATGAATAAACTGTATGACAAAATCCCTCCTTCCGTGTGGAAATTTGTCCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT228267 WP_002892066.1 NZ_CP089441:3875097-3875471 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT228267 NZ_CP123598:c2389960-2389586 [Enterobacter cloacae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAATCATGGCTGGGTGAACGATCCAACATCGGCCATCAATTTGCAATTGAATGAGTTGATAGAGC
ATATCGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAGCAAATTGACGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCGCAGGATTTGCAGAAATGGCGTAAATCTGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References