Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 778068..778725 Replicon chromosome
Accession NZ_CP089441
Organism Klebsiella quasipneumoniae strain GLW9C22

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LT990_RS03865 Protein ID WP_023290968.1
Coordinates 778315..778725 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LT990_RS03860 Protein ID WP_002916312.1
Coordinates 778068..778334 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT990_RS03835 (773218) 773218..774651 - 1434 WP_101989439.1 6-phospho-beta-glucosidase -
LT990_RS03840 (774770) 774770..775498 - 729 WP_049014197.1 MurR/RpiR family transcriptional regulator -
LT990_RS03845 (775549) 775549..775860 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
LT990_RS03850 (776024) 776024..776683 + 660 WP_008806429.1 hemolysin III family protein -
LT990_RS03855 (776839) 776839..777822 - 984 WP_023290969.1 tRNA-modifying protein YgfZ -
LT990_RS03860 (778068) 778068..778334 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LT990_RS03865 (778315) 778315..778725 + 411 WP_023290968.1 protein YgfX Toxin
LT990_RS03870 (778732) 778732..779253 - 522 WP_004205324.1 flavodoxin FldB -
LT990_RS03875 (779354) 779354..780250 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
LT990_RS03880 (780273) 780273..780986 + 714 WP_087826632.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LT990_RS03885 (780992) 780992..782725 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T228255 WP_023290968.1 NZ_CP089441:778315-778725 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228255 NZ_CP123597:3747540-3747851 [Serratia marcescens]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAACAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGTCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228255 WP_002916312.1 NZ_CP089441:778068-778334 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228255 NZ_CP123597:3747848-3748270 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATACCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCATATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References