Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 706517..707295 Replicon chromosome
Accession NZ_CP089441
Organism Klebsiella quasipneumoniae strain GLW9C22

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LT990_RS03520 Protein ID WP_101989453.1
Coordinates 706807..707295 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LT990_RS03515 Protein ID WP_049014236.1
Coordinates 706517..706810 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT990_RS03495 (701740) 701740..702342 - 603 WP_032454058.1 short chain dehydrogenase -
LT990_RS03500 (702440) 702440..703351 + 912 WP_044524712.1 LysR family transcriptional regulator -
LT990_RS03505 (703352) 703352..704500 - 1149 WP_087826667.1 PLP-dependent aspartate aminotransferase family protein -
LT990_RS03510 (704511) 704511..705887 - 1377 WP_165454422.1 cystathionine beta-synthase -
LT990_RS03515 (706517) 706517..706810 + 294 WP_049014236.1 DUF1778 domain-containing protein Antitoxin
LT990_RS03520 (706807) 706807..707295 + 489 WP_101989453.1 GNAT family N-acetyltransferase Toxin
LT990_RS03525 (707606) 707606..707857 - 252 WP_087826663.1 hypothetical protein -
LT990_RS03530 (708029) 708029..712069 - 4041 WP_087826662.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 700921..712069 11148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17508.38 Da        Isoelectric Point: 7.7559

>T228254 WP_101989453.1 NZ_CP089441:706807-707295 [Klebsiella quasipneumoniae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKLRAMKNQTTGASRTFVCCGSDSNVLAFYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T228254 NZ_CP123597:c3413766-3413344 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTAACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCTCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGATCGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGACTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAATGGCGCCACCTGCGGCAGCTGTTGCTGTATCCACCGG
CGGGTGACGGCGAGGAGTCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10914.54 Da        Isoelectric Point: 9.8590

>AT228254 WP_049014236.1 NZ_CP089441:706517-706810 [Klebsiella quasipneumoniae]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQTPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT228254 NZ_CP123597:c3414013-3413747 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATTTCCATCATGCCGTT
TTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References