Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4950930..4951546 Replicon chromosome
Accession NZ_CP089437
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LT980_RS23975 Protein ID WP_020996118.1
Coordinates 4950930..4951304 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LT980_RS23980 Protein ID WP_020996119.1
Coordinates 4951304..4951546 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS23960 (LT980_23950) 4948433..4949335 + 903 WP_003825273.1 formate dehydrogenase O subunit beta -
LT980_RS23965 (LT980_23955) 4949332..4949967 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LT980_RS23970 (LT980_23960) 4949964..4950893 + 930 WP_237857414.1 formate dehydrogenase accessory protein FdhE -
LT980_RS23975 (LT980_23965) 4950930..4951304 - 375 WP_020996118.1 type II toxin-antitoxin system VapC family toxin Toxin
LT980_RS23980 (LT980_23970) 4951304..4951546 - 243 WP_020996119.1 CopG family transcriptional regulator Antitoxin
LT980_RS23985 (LT980_23975) 4951752..4952681 + 930 WP_250671534.1 alpha/beta hydrolase -
LT980_RS23990 (LT980_23980) 4952766..4953077 + 312 WP_250671535.1 type II toxin-antitoxin system HigB family toxin -
LT980_RS23995 (LT980_23985) 4953074..4953520 + 447 WP_048215203.1 helix-turn-helix domain-containing protein -
LT980_RS24000 (LT980_23990) 4953538..4954479 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LT980_RS24005 (LT980_23995) 4954524..4954961 - 438 WP_003825289.1 D-aminoacyl-tRNA deacylase -
LT980_RS24010 (LT980_24000) 4954958..4955830 - 873 WP_008786998.1 virulence factor BrkB family protein -
LT980_RS24015 (LT980_24005) 4955824..4956423 - 600 WP_008786997.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13648.86 Da        Isoelectric Point: 9.6927

>T228249 WP_020996118.1 NZ_CP089437:c4951304-4950930 [Citrobacter portucalensis]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEHGMKLPDAIILATAQIHRLTLVTRNTKDFAGISGVVTPYTL

Download         Length: 375 bp

>T228249 NZ_CP123597:1207228-1207324 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9479.80 Da        Isoelectric Point: 4.3437

>AT228249 WP_020996119.1 NZ_CP089437:c4951546-4951304 [Citrobacter portucalensis]
MMVGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT228249 NZ_CP123597:c1207324-1207184 [Serratia marcescens]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References