Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2605080..2605816 Replicon chromosome
Accession NZ_CP089437
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LT980_RS12585 Protein ID WP_250670925.1
Coordinates 2605334..2605816 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LT980_RS12580 Protein ID WP_250670924.1
Coordinates 2605080..2605346 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS12560 (LT980_12555) 2600132..2601319 + 1188 WP_250670921.1 outer membrane protein transport protein -
LT980_RS12565 (LT980_12560) 2601557..2602186 + 630 WP_008784772.1 winged helix-turn-helix transcriptional regulator -
LT980_RS12570 (LT980_12565) 2602303..2602689 - 387 WP_250670922.1 hypothetical protein -
LT980_RS12575 (LT980_12570) 2602944..2604926 + 1983 WP_250670923.1 alkyl sulfatase dimerization domain-containing protein -
LT980_RS12580 (LT980_12575) 2605080..2605346 + 267 WP_250670924.1 DUF1778 domain-containing protein Antitoxin
LT980_RS12585 (LT980_12580) 2605334..2605816 + 483 WP_250670925.1 GNAT family N-acetyltransferase Toxin
LT980_RS12590 (LT980_12585) 2606114..2607301 - 1188 WP_079934034.1 outer membrane protein transport protein -
LT980_RS12595 (LT980_12590) 2607394..2608509 - 1116 WP_250670926.1 DUF4056 domain-containing protein -
LT980_RS12600 (LT980_12595) 2608510..2609622 - 1113 WP_250670927.1 BamA/TamA family outer membrane protein -
LT980_RS12605 (LT980_12600) 2609640..2610578 - 939 WP_250670928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17643.48 Da        Isoelectric Point: 9.8713

>T228244 WP_250670925.1 NZ_CP089437:2605334-2605816 [Citrobacter portucalensis]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGTARTFVVCKTDTRKVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

>T228244 NZ_CP123568:c2933-2757 [Arsenophonus nasoniae]
GTGAAACAAAGCGAGTTTCTTAAGTGGTTGAAGTCACAAGGCGTTAAAACTGAAAACGGTAAAAAACATTTGAGACTCTA
CTACAAAGGTAAAATAAGCCATCTCCCAAGACACGGAAGTCAAGAGTTAACGACGGGATTAGTTGAAGGCGTAAAAAAAC
AGCTAGGCTTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10163.64 Da        Isoelectric Point: 4.6558

>AT228244 WP_250670924.1 NZ_CP089437:2605080-2605346 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKTQWDL

Download         Length: 267 bp

>AT228244 NZ_CP123568:c2691-2275 [Arsenophonus nasoniae]
ATGTTTTATCCAGCAAAATTTACCCAAGAAGATAATGGTTATACTGTCTCTTTTAGAGATATAAAAGACGCAATCACTTG
CGGTTCATCTTTCGATGAAGCCATGTCGATGGCGGAAGATATTATTTTGTGTTGGATAGATGTTTACTTTGAAAAAAATG
AATTTGTTCCTATGCCATCAGATAGTTTATATGATTATGAACATTGGGTATTTTTACCTGACAGCATTTTTGCTAAAGTT
TTATTACATAATGAAATGCTAAAAGCTAAAATTTCCAAAGCTGAGTTAGCTAGATTGATGGGTACAAATTCGCCAGAGAT
TCAAAGAATTTTATCTGCAAGACACAAAACGAAAATTGACACCATTAGTAAAGCATTATCAAAATTAGGTAAACATTTAA
CACTCTCTTTAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References