Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1753431..1754093 Replicon chromosome
Accession NC_010582
Organism Streptococcus pneumoniae CGSP14

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SPCG_RS09155 Protein ID WP_000192223.1
Coordinates 1753920..1754093 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPCG_RS09150 Protein ID WP_000961810.1
Coordinates 1753431..1753883 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPCG_RS09130 1750280..1751314 - 1035 WP_000747915.1 ATP-binding protein -
SPCG_RS09135 1751424..1751582 - 159 WP_000418165.1 hypothetical protein -
SPCG_RS09140 1751563..1752651 - 1089 WP_000738088.1 site-2 protease family protein -
SPCG_RS09145 1752670..1753140 - 471 WP_000257097.1 DUF3013 family protein -
SPCG_RS09150 1753431..1753883 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPCG_RS09155 1753920..1754093 - 174 WP_000192223.1 type II toxin-antitoxin system HicA family toxin Toxin
SPCG_RS09160 1754236..1754415 - 180 WP_001809903.1 hypothetical protein -
SPCG_RS09165 1754580..1754822 - 243 WP_000818082.1 hypothetical protein -
SPCG_RS09170 1755092..1756363 + 1272 WP_001113178.1 replication-associated recombination protein A -
SPCG_RS09180 1756908..1758227 - 1320 WP_000502559.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6398.50 Da        Isoelectric Point: 10.8214

>T22824 WP_000192223.1 NC_010582:c1754093-1753920 [Streptococcus pneumoniae CGSP14]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHSELNKYTERGIGKQAGL

Download         Length: 174 bp

>T22824 NC_010582:c1754093-1753920 [Streptococcus pneumoniae CGSP14]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATAGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT22824 WP_000961810.1 NC_010582:c1753883-1753431 [Streptococcus pneumoniae CGSP14]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT22824 NC_010582:c1753883-1753431 [Streptococcus pneumoniae CGSP14]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References