Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/GNAT-DUF1778
Location 227719..228470 Replicon plasmid p1194_1
Accession NZ_CP089428
Organism Klebsiella pneumoniae strain 1194

Toxin (Protein)


Gene name ataT Uniprot ID A0A8T3UHS1
Locus tag A9X66_RS27025 Protein ID WP_004883482.1
Coordinates 227719..228201 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8T3UKU4
Locus tag A9X66_RS27030 Protein ID WP_004883484.1
Coordinates 228192..228470 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X66_RS27010 (A9X66_027010) 223545..225278 + 1734 WP_025368656.1 PP2C family serine/threonine-protein phosphatase -
A9X66_RS27015 (A9X66_027015) 225306..226805 + 1500 WP_004196935.1 lipopolysaccharide kinase InaA family protein -
A9X66_RS27020 (A9X66_027020) 227184..227666 + 483 WP_004196929.1 hypothetical protein -
A9X66_RS27025 (A9X66_027025) 227719..228201 - 483 WP_004883482.1 GNAT family N-acetyltransferase Toxin
A9X66_RS27030 (A9X66_027030) 228192..228470 - 279 WP_004883484.1 DUF1778 domain-containing protein Antitoxin
A9X66_RS27035 (A9X66_027035) 228986..229954 - 969 WP_234552789.1 IS5 family transposase -
A9X66_RS27040 (A9X66_027040) 230759..231034 - 276 WP_001141269.1 formaldehyde-responsive transcriptional repressor FrmR -
A9X66_RS28590 232735..233109 - 375 WP_227522231.1 DUF488 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / sul1 / qacE / aadA2 / dfrA15 / ARR-3 / dfrA8 / rmtG / sul2 / catA1 / formA - 1..266289 266289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(69-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17491.36 Da        Isoelectric Point: 9.4950

>T228230 WP_004883482.1 NZ_CP089428:c228201-227719 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVINEWLKKKALRNHGTGISRVFVVCSENSKRVIAYYCLSSGSVHRNTVTGTYRRNAP
AAIPVIVLGRLAVDAAWAGKGIGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVVAFYTKFGFETSAVNALTLLFPVKV

Download         Length: 483 bp

>T228230 NZ_CP123544:2880959-2881162 [Arsenophonus nasoniae]
ATGACTAAAATTGACTATCTGATGCGCTTAAGAAAATGTACGACTATCGAAACATTGGAGCGCGTAATCGAAAAAAACAA
ATATGAATTATCTGAAGACGAACTTGAGTTATTTTATTCTGCTGCCGACCATAGGTTAGCAGAACTCACAATGAATAAAC
TTTATGACAAAATTCCTTCGTCAGTTTGGAAGTATGTTCGCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10720.23 Da        Isoelectric Point: 4.5423

>AT228230 WP_004883484.1 NZ_CP089428:c228470-228192 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFLLDDKQFDTFIEELDAPVTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT228230 NZ_CP123544:2880534-2880902 [Arsenophonus nasoniae]
ATGGATGAGTACTCACCAAGGAGTTATGACATCTTAGTGCTAAAGTATTTATGTGATGCTCTACATCGTGATGCGATGTT
AACTTTGCATAGGACAAAAACCCATTGGAAGAATGATCTTGGTTCCGACCAAAACGTTAAATTTAATGTATTAATTGATC
ATATCACAGATTTTATTGGTCAATTTAAATTAAAATATCCGAATAACGTAAATCTTTTTATTTTTATTGACGAATATTTG
GATGAAACTTATAACCTATTTGGTAAACCTGTAATGAGCCTAACAGATATTTCTGATTGGCAAAAAATGAATGAGCATTT
GTCTGAAATATTAACAAATGATATAAAGTATTCATTAAGTAACACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References