Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 153475..154001 | Replicon | plasmid p1194_1 |
| Accession | NZ_CP089428 | ||
| Organism | Klebsiella pneumoniae strain 1194 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | A9X66_RS26670 | Protein ID | WP_000323025.1 |
| Coordinates | 153714..154001 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | A9X66_RS26665 | Protein ID | WP_004196370.1 |
| Coordinates | 153475..153714 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A9X66_RS26630 (A9X66_026630) | 148812..149004 | - | 193 | Protein_152 | MFS transporter | - |
| A9X66_RS26635 (A9X66_026635) | 149034..150011 | + | 978 | WP_004196334.1 | chromate resistance protein | - |
| A9X66_RS26640 (A9X66_026640) | 149968..151344 | + | 1377 | WP_004196363.1 | chromate efflux transporter | - |
| A9X66_RS26645 (A9X66_026645) | 151375..152064 | - | 690 | WP_004196322.1 | hypothetical protein | - |
| A9X66_RS26650 (A9X66_026650) | 152078..152815 | - | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| A9X66_RS26655 (A9X66_026655) | 152859..153224 | - | 366 | WP_009651956.1 | hypothetical protein | - |
| A9X66_RS26660 (A9X66_026660) | 153352..153450 | - | 99 | Protein_158 | hypothetical protein | - |
| A9X66_RS26665 (A9X66_026665) | 153475..153714 | + | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| A9X66_RS26670 (A9X66_026670) | 153714..154001 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| A9X66_RS26675 (A9X66_026675) | 154073..154231 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| A9X66_RS26680 (A9X66_026680) | 154837..155811 | + | 975 | WP_004196336.1 | hypothetical protein | - |
| A9X66_RS28585 | 155795..155917 | + | 123 | WP_254911979.1 | hypothetical protein | - |
| A9X66_RS26685 (A9X66_026685) | 156009..156386 | - | 378 | WP_004196351.1 | hypothetical protein | - |
| A9X66_RS26690 (A9X66_026690) | 157076..158143 | + | 1068 | WP_004181903.1 | hypothetical protein | - |
| A9X66_RS26695 (A9X66_026695) | 158299..158646 | + | 348 | WP_069217495.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / sul1 / qacE / aadA2 / dfrA15 / ARR-3 / dfrA8 / rmtG / sul2 / catA1 / formA | - | 1..266289 | 266289 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T228229 WP_000323025.1 NZ_CP089428:153714-154001 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T228229 NZ_CP123544:c2640838-2640431 [Arsenophonus nasoniae]
GTGGTTCTTTGGAAATTTAATATCAATGTTTCGTGGCTGACGCAGCTTTTTTCAACGGGTGTTCATGTGGGAATTGGCTT
GTTAGTTTTCTTTTCATCTTGGCCACCAAATAATCTGGTCACTTGGTTGATAGCGACCTTATTGATTGTGGCAAGTTGGG
TAAGGAGTCAAAAAAATATTAGTCGTTGTAAAGGTAGCATAGTTTTACTTAATGGTAATAAGATACAGTGGAAAAAAAGC
GAATGGCTGATTGTTAAAAAACCTTGGTTTTGTTTTTTTGGTGTAAAACTTACTCTTCGTTCATGGCAATGTAATAAGCG
GATTCGGTTATGGATTGCTTCAGATAGTATGCCAGAAGAGGAATGGCGGAATTTAAATCAATTGCTGTTGCAGTACCCTG
ATATTTGA
GTGGTTCTTTGGAAATTTAATATCAATGTTTCGTGGCTGACGCAGCTTTTTTCAACGGGTGTTCATGTGGGAATTGGCTT
GTTAGTTTTCTTTTCATCTTGGCCACCAAATAATCTGGTCACTTGGTTGATAGCGACCTTATTGATTGTGGCAAGTTGGG
TAAGGAGTCAAAAAAATATTAGTCGTTGTAAAGGTAGCATAGTTTTACTTAATGGTAATAAGATACAGTGGAAAAAAAGC
GAATGGCTGATTGTTAAAAAACCTTGGTTTTGTTTTTTTGGTGTAAAACTTACTCTTCGTTCATGGCAATGTAATAAGCG
GATTCGGTTATGGATTGCTTCAGATAGTATGCCAGAAGAGGAATGGCGGAATTTAAATCAATTGCTGTTGCAGTACCCTG
ATATTTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT228229 WP_004196370.1 NZ_CP089428:153475-153714 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT228229 NZ_CP123544:c2641085-2640819 [Arsenophonus nasoniae]
ATGGATATCAATCATAAACCCAGGATCCACTGGGCATGTCGCAGAGGAATGCGTGAGTTGGACATCGCCATTATGCCTTT
TTTTGAGTATGAATATGATTCACTCACAGAGGATGAGAAATGTCTGTTTGTTCGTTTACTAGAGTGTGCAGATCCTGATT
TGTTCAACTGGTTGATGAATCATGGGCGTCCTGATGATGATGGTCTTTATCATATGATTCAATTGATACAGAGTAGAAAT
AAACAACGTGGTTCTTTGGAAATTTAA
ATGGATATCAATCATAAACCCAGGATCCACTGGGCATGTCGCAGAGGAATGCGTGAGTTGGACATCGCCATTATGCCTTT
TTTTGAGTATGAATATGATTCACTCACAGAGGATGAGAAATGTCTGTTTGTTCGTTTACTAGAGTGTGCAGATCCTGATT
TGTTCAACTGGTTGATGAATCATGGGCGTCCTGATGATGATGGTCTTTATCATATGATTCAATTGATACAGAGTAGAAAT
AAACAACGTGGTTCTTTGGAAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|