Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-DnaT |
Location | 44543..45065 | Replicon | plasmid p1194_1 |
Accession | NZ_CP089428 | ||
Organism | Klebsiella pneumoniae strain 1194 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A2J4R0S6 |
Locus tag | A9X66_RS26115 | Protein ID | WP_004181778.1 |
Coordinates | 44781..45065 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A5Q9LM53 |
Locus tag | A9X66_RS26110 | Protein ID | WP_025368601.1 |
Coordinates | 44543..44791 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A9X66_RS26090 (A9X66_026090) | 39752..40588 | - | 837 | WP_223686625.1 | hypothetical protein | - |
A9X66_RS26095 (A9X66_026095) | 40635..40988 | - | 354 | WP_004181774.1 | hypothetical protein | - |
A9X66_RS26100 (A9X66_026100) | 41133..42119 | - | 987 | WP_025368599.1 | hypothetical protein | - |
A9X66_RS26105 (A9X66_026105) | 42453..44252 | - | 1800 | WP_025368600.1 | ATP-dependent helicase | - |
A9X66_RS26110 (A9X66_026110) | 44543..44791 | + | 249 | WP_025368601.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
A9X66_RS26115 (A9X66_026115) | 44781..45065 | + | 285 | WP_004181778.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A9X66_RS26120 (A9X66_026120) | 45295..46521 | + | 1227 | WP_025368602.1 | RNA-guided endonuclease TnpB family protein | - |
A9X66_RS26125 (A9X66_026125) | 46807..47232 | - | 426 | WP_040120489.1 | IS200/IS605 family transposase | - |
A9X66_RS26130 (A9X66_026130) | 47269..48495 | + | 1227 | WP_025368604.1 | RNA-guided endonuclease TnpB family protein | - |
A9X66_RS26135 (A9X66_026135) | 48561..49687 | - | 1127 | Protein_52 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / sul1 / qacE / aadA2 / dfrA15 / ARR-3 / dfrA8 / rmtG / sul2 / catA1 / formA | - | 1..266289 | 266289 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10970.69 Da Isoelectric Point: 10.6516
>T228227 WP_004181778.1 NZ_CP089428:44781-45065 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
Download Length: 285 bp
>T228227 NZ_CP123527:c24796-24620 [Arsenophonus nasoniae]
GTGAAACAAAGCGAGTTTCTTAAGTGGTTGAAGTCACAAGGCGTTAAAACTGAAAACGGTAAAAAACATTTGAGACTCTA
CTACAAAGGTAAAATAAGCCATCTCCCAAGACACGGAAGTCAAGAGTTAACGACGGGATTAGTTGAAGGCGTAAAAAAAC
AGCTAGGCTTGAAATAA
GTGAAACAAAGCGAGTTTCTTAAGTGGTTGAAGTCACAAGGCGTTAAAACTGAAAACGGTAAAAAACATTTGAGACTCTA
CTACAAAGGTAAAATAAGCCATCTCCCAAGACACGGAAGTCAAGAGTTAACGACGGGATTAGTTGAAGGCGTAAAAAAAC
AGCTAGGCTTGAAATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8906.12 Da Isoelectric Point: 3.8206
>AT228227 WP_025368601.1 NZ_CP089428:44543-44791 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
Download Length: 249 bp
>AT228227 NZ_CP123527:c24554-24138 [Arsenophonus nasoniae]
ATGTTTTATCCAGCAAAATTTACCCAAGAAGATAATGGTTATACTGTCTCTTTTAGAGATATAAAAGACGCAATCACTTG
CGGTTCATCTTTCGATGAAGCCATGTCGATGGCGGAAGATATTATTTTGTGTTGGATAGATGTTTACTTTGAAAAAAATG
AATTTGTTCCTATGCCATCAGATAGTTTATATGATTATGAACATTGGGTATTTTTACCTGACAGCATTTTTGCTAAAGTT
TTATTACATAATGAAATGCTAAAAGCTAAAATTTCCAAAGCTGAGTTAGCTAGATTGATGGGTACAAATTCGCCAGAGAT
TCAAAGAATTTTATCTGCAAGACACAAAACGAAAATTGACACCATTAGTAAAGCATTATCAAAATTAGGTAAACATTTAA
CACTCTCTTTAGCGTGA
ATGTTTTATCCAGCAAAATTTACCCAAGAAGATAATGGTTATACTGTCTCTTTTAGAGATATAAAAGACGCAATCACTTG
CGGTTCATCTTTCGATGAAGCCATGTCGATGGCGGAAGATATTATTTTGTGTTGGATAGATGTTTACTTTGAAAAAAATG
AATTTGTTCCTATGCCATCAGATAGTTTATATGATTATGAACATTGGGTATTTTTACCTGACAGCATTTTTGCTAAAGTT
TTATTACATAATGAAATGCTAAAAGCTAAAATTTCCAAAGCTGAGTTAGCTAGATTGATGGGTACAAATTCGCCAGAGAT
TCAAAGAATTTTATCTGCAAGACACAAAACGAAAATTGACACCATTAGTAAAGCATTATCAAAATTAGGTAAACATTTAA
CACTCTCTTTAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4R0S6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Q9LM53 |