Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 44543..45065 Replicon plasmid p1194_1
Accession NZ_CP089428
Organism Klebsiella pneumoniae strain 1194

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag A9X66_RS26115 Protein ID WP_004181778.1
Coordinates 44781..45065 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag A9X66_RS26110 Protein ID WP_025368601.1
Coordinates 44543..44791 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X66_RS26090 (A9X66_026090) 39752..40588 - 837 WP_223686625.1 hypothetical protein -
A9X66_RS26095 (A9X66_026095) 40635..40988 - 354 WP_004181774.1 hypothetical protein -
A9X66_RS26100 (A9X66_026100) 41133..42119 - 987 WP_025368599.1 hypothetical protein -
A9X66_RS26105 (A9X66_026105) 42453..44252 - 1800 WP_025368600.1 ATP-dependent helicase -
A9X66_RS26110 (A9X66_026110) 44543..44791 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A9X66_RS26115 (A9X66_026115) 44781..45065 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9X66_RS26120 (A9X66_026120) 45295..46521 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
A9X66_RS26125 (A9X66_026125) 46807..47232 - 426 WP_040120489.1 IS200/IS605 family transposase -
A9X66_RS26130 (A9X66_026130) 47269..48495 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
A9X66_RS26135 (A9X66_026135) 48561..49687 - 1127 Protein_52 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / sul1 / qacE / aadA2 / dfrA15 / ARR-3 / dfrA8 / rmtG / sul2 / catA1 / formA - 1..266289 266289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T228227 WP_004181778.1 NZ_CP089428:44781-45065 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T228227 NZ_CP123527:c24796-24620 [Arsenophonus nasoniae]
GTGAAACAAAGCGAGTTTCTTAAGTGGTTGAAGTCACAAGGCGTTAAAACTGAAAACGGTAAAAAACATTTGAGACTCTA
CTACAAAGGTAAAATAAGCCATCTCCCAAGACACGGAAGTCAAGAGTTAACGACGGGATTAGTTGAAGGCGTAAAAAAAC
AGCTAGGCTTGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT228227 WP_025368601.1 NZ_CP089428:44543-44791 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT228227 NZ_CP123527:c24554-24138 [Arsenophonus nasoniae]
ATGTTTTATCCAGCAAAATTTACCCAAGAAGATAATGGTTATACTGTCTCTTTTAGAGATATAAAAGACGCAATCACTTG
CGGTTCATCTTTCGATGAAGCCATGTCGATGGCGGAAGATATTATTTTGTGTTGGATAGATGTTTACTTTGAAAAAAATG
AATTTGTTCCTATGCCATCAGATAGTTTATATGATTATGAACATTGGGTATTTTTACCTGACAGCATTTTTGCTAAAGTT
TTATTACATAATGAAATGCTAAAAGCTAAAATTTCCAAAGCTGAGTTAGCTAGATTGATGGGTACAAATTCGCCAGAGAT
TCAAAGAATTTTATCTGCAAGACACAAAACGAAAATTGACACCATTAGTAAAGCATTATCAAAATTAGGTAAACATTTAA
CACTCTCTTTAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References